Lecture 10b to post [Compatibility Mode]

Lecture 10b to post [Compatibility Mode] - Role as a...

Info iconThis preview shows pages 1–3. Sign up to view the full content.

View Full Document Right Arrow Icon
Role as a transcription factor: extrinsic apoptotic signaling p53 shown to upregulate expression:Fas receptor, Fas Ligand and pro-apoptotic TRAIL binding DR4 and DR5 receptors
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Role of p53 in ROS-the PIGs!! Two schools of thought: 1. p53 can induce redox-related genes 2. increased production of reactive oxygen species oxidative degradation of mitochondrial components 3. 4. apoptosis OR 1. p53 can induce genes associated with anti-oxidant defense e.g. hydrogen peroxide is reduced to water and oxygen by the glutathione (GSH) antioxidant system order to maintain the defense against H2O2 -in order to maintain the defense against H2O2, glutathione peroxidases restore GSH levels by reducing oxidized glutathione p53 can upregulate glutathione peroxidase -thus, antioxidant genes regulated by p53 may limit the amount of cellular stress and DNA damage by ROS. -p53 regulation of ROS could provide another means
Background image of page 2
Image of page 3
This is the end of the preview. Sign up to access the rest of the document.

This note was uploaded on 12/03/2010 for the course PHAMACOLOG pcl470 taught by Professor Arnot during the Fall '10 term at University of Toronto- Toronto.

Page1 / 6

Lecture 10b to post [Compatibility Mode] - Role as a...

This preview shows document pages 1 - 3. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online