Lecture 10b to post [Compatibility Mode]

Lecture 10b to post [Compatibility Mode] - Role as a...

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Role as a transcription factor: t i i t ti i li extrinsic apoptotic signaling p53 shown to upregulate expression:Fas receptor, Fas Ligand and pro-apoptotic TRAIL binding DR4 and DR5 receptors
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Role of p53 in ROS-the PIGs!! Two schools of thought: 1. p53 can induce redox-related genes 2. increased production of reactive oxygen species 3 oxidative degradation of mitochondrial components 3. 4. apoptosis OR 1. p53 can induce genes associated with anti-oxidant defense e.g. hydrogen peroxide is reduced to water and oxygen by the glutathione (GSH) antioxidant system in order to maintain the defense against H2O2 -in order to maintain the defense against H2O2, glutathione peroxidases restore GSH levels by reducing oxidized glutathione p53 can upregulate glutathione peroxidase -thus, antioxidant genes regulated by p53 may limit the amount of cellular stress and DNA damage by ROS. -p53 regulation of ROS could provide another means through which p53 can modulate cell survival or cell death following DNA damage.
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