PCL477H1-Lecture 8a to post - Lecture 8 overview Damage...

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Lecture 8 overview • Damage sensors and transducers • Relationship of genome surveillance to DNA repair mechanisms • Activation of checkpoints by DNA damage sensors
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How is DNA damage recognized and converted to cellular responses? G1, S, and G2/M Cell cycle arrest
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Transmission of the DNA damage response signal Phosphorylation (kinases, phosphatases) Acetylation (e.g. histones) Ubiquitination e.g. cdc25 Mobilization and relocalization – recruitment of member proteins in a pathway to a complex at the site of DNA damage Transcription – e.g. p21
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Attenuation of DNA damage response Sensors Transducers Effectors Feedback Attenuation DNA repair Cell cycle arrest Apoptosis Damage
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p53 is a ‘master’ effector Sensors Transducers Effectors DNA repair Cell cycle arrest Apoptosis Damage p53 Transcription factor Tumour suppressor
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p53 is a ‘master’ effector Sensors Transducers Effectors DNA repair Cell cycle arrest Apoptosis Damage p53 Increase in levels Transcription factor Tumour suppressor p21:G1 arrest 14-3-3: G2 arrest Repair proteins pro-apoptotic genes
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This note was uploaded on 12/03/2010 for the course PHAMACOLOG pcl470 taught by Professor Arnot during the Fall '10 term at University of Toronto.

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PCL477H1-Lecture 8a to post - Lecture 8 overview Damage...

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