handout10-DNA - Bio 311C, Buskirk What data contributed to...

Info iconThis preview shows pages 1–2. Sign up to view the full content.

View Full Document Right Arrow Icon
Bio 311C, Buskirk What data contributed to knowledge of DNA structure? (Double Helix) Knowledge from organic chemistry; composition of a nucleotide : a 5-carbon sugar (deoxyribose), a phosphate, and nitrogenous base (a double ring or single ring of N, C and H) purines (double ring) A=adenine, G=guanine pyrimidines (single ring) T=thymine, C=cytosine [Learn the 1’,3’ (3 prime), 5’ (5 prime) notation] from Linus Pauling : by 1950, Chargaff's Rules: [A=T C=G ] •the idea to build a 3-dimensional model the proportion of different nitrogenous bases •compare predicted model with lab measures in DNA is species-specific. The amount of •in 1951, found alpha helix form of proteins adenine equals the amount of thymine, and the % cytosine equals % guanine, e.g., in humans, from M. Wilkins' lab: approximately 30% A, 30% T, 20% C, 20% G •Wilkins prepared uniformly aligned DNA fibers, best samples for crystalline DNA From biochemistry laboratories: •Rosalind Franklin performed the best, most
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Image of page 2
This is the end of the preview. Sign up to access the rest of the document.

This note was uploaded on 12/03/2010 for the course BIO 311C taught by Professor Satasivian during the Fall '08 term at University of Texas at Austin.

Page1 / 2

handout10-DNA - Bio 311C, Buskirk What data contributed to...

This preview shows document pages 1 - 2. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online