This preview shows pages 1–2. Sign up to view the full content.
This preview has intentionally blurred sections. Sign up to view the full version.View Full Document
Unformatted text preview: Bio 311C Buskirk Handout 14 Signal Transduction Nov 12, 15 also for homework due Wed 11/17 in lieu of disc section meetings no disc meetings Nov. 15-16 th ! Text Chap 11 pages. 209-210, 214-216, concept check 11.3. You may also read (and critique) concepts 5.5 and 5.6 of the sample chapter preview booklet from publishers Sinauer & WH Freeman. Signal Transduction: A signal molecule outside the cell (the "first messenger") binds to a membrane receptor, affects a relay system and effector molecules in the membrane, and triggers activation of a second messenger and a cascade of chemical reactions inside the cell. Basic essential steps of signal transduction pathways An external signal molecule binds a membrane receptor protein, changing its conformation. This change in the receptor protein affects membrane relay and effector proteins that immediately activate second messengers. One common relay system is the G protein. Second messengers are small, non-protein molecules such as cyclic AMP (cAMP) and Ca++ ions that are soluble in the cytoplasm. Second messengers are released in the cytoplasm and activate kinase enzymes....
View Full Document
- Fall '08