Handout14signalTransduction

Handout14signalTransduction - Bio 311C Buskirk Handout 14...

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Bio 311C Buskirk Handout 14 – Signal Transduction Nov 12, 15 also for homework due Wed 11/17 in lieu of disc section meetings – no disc meetings Nov. 15-16 th ! Text Chap 11 pages. 209-210, 214-216, concept check 11.3. You may also read (and critique) concepts 5.5 and 5.6 of the sample chapter preview booklet from publishers Sinauer & WH Freeman. Signal Transduction: A signal molecule outside the cell (the "first messenger") binds to a membrane receptor, affects a relay system and effector molecules in the membrane, and triggers activation of a second messenger and a cascade of chemical reactions inside the cell. Basic essential steps of signal transduction pathways •An external signal molecule binds a membrane receptor protein, changing its conformation. •This change in the receptor protein affects membrane relay and effector proteins that immediately activate second messengers. One common relay system is the G protein. •Second messengers are small, non-protein molecules such as cyclic AMP (cAMP) and Ca++ ions that are soluble in the cytoplasm. Second messengers are released in the cytoplasm and activate kinase enzymes.
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