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Sci255_Lecture2-10

Sci255_Lecture2-10 - BIOLOGY OF AGING LECTURE 2 BIOLOGY...

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BIOLOGY OF AGING LECTURE 2 BIOLOGY OF AGING LECTURE 2
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Remember Chronological age is NOT equal to Biological Age chronological age is based on time only biological age is based on functional capacity of the individual Functional capacity Functional capacity is a direct measure of the ability of our cells, is a direct measure of the ability of our cells, tissues, and organ systems to function properly/optimally tissues, and organ systems to function properly/optimally Functional capacity and aging are greatly influenced by extrinsic factors extrinsic factors and to a lesser extent intrinsic factors intrinsic factors
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Some factors which effect the time of onset, rate and Some factors which effect the time of onset, rate and extent of biological aging extent of biological aging Individual Physiological Age Rate Onset Extent Intrinsic Genetics (DNA) No control Longevity genes Death genes Race Gender Predisposition to disease Extrinsic Environment Pollution, smog, toxins, sunlight Infections, viruses, pneumonia Trauma, accidents Medical advancements Organ replacements Heart surgery Extrinsic Lifestyles/Nutrition Education Diet/Nutrition Exercise Alcohol/Drugs Stress Smoking Occupation Control over:
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Overview of Normal Aging Process    decline of functional properties loss of homeostasis decreased ability to adapt to internal/external stimuli increased vulnerability to disease and mortality Extrinsic Factors Extrinsic Factors Lifestyle: diet, stress, exercise Intrinsic Factors Intrinsic Factors Genetics: Fixed positive or negative Extrinsic Factors Environmental Factors: temp, drugs, trauma, toxins, radiation Aging of Organism
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Definition of Normal Biological Aging Definition of Normal Biological Aging : Aging is defined as the decline and deterioration of functional properties at the cellular, tissue and organ level structural elements within the body deteriorate The reduced capacity of elderly to respond to changing internal and external environments makes it difficult for them to maintain stable chemical and physical states within body ( homeostasis ) Loss of functional capacity with age results in a decreased ability of the elderly to adapt to both internal and external internal and external stressors In absence of homeostasis, dysfunction of cells, organs and systems is more likely with age, which increases likelihood of disease and death Leads To Leads To:
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