Sci255_Lecture3-10

Sci255_Lecture3-10 - BIOLOGY OF AGING LECTURE 3 BIOLOGY OF...

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Unformatted text preview: BIOLOGY OF AGING LECTURE 3 BIOLOGY OF AGING LECTURE 3 decline of functional properties loss of homeostasis decreased ability to adapt to internal/external stimuli increased vulnerability to disease and mortality Overview of Normal Aging Process Described as the ability to maintain relatively stable internal conditions even in the face of large continuous changes in the outside environment unchanging Examples of Homeostasis: Examples of Homeostasis: Stressors Balance 2.Communication within body by nervous and endocrine systems control system made up of at least 3 interdependent components Detecting Detecting presence of deviations from homeostasis (sensor sensor ) monitors environment responds to changes (stimuli) sends input to controller receptors (sense change in body) Integration Integration of of information, analyzing if the condition is unacceptable, how to correct (respond) maintains setpoint usually part of brain Effector Effector : provides means by which controller can cause response (output) to stimulus to return to normal A Normal Negative Feedback System For Thermoregulation Thermoregulation Overheating: vasodilation heat lost sweating hair on skin stands up Homeostasis restored Sweat gland inactive Stimulus/receptor Nerve cells in base of brain ( Control Center) Effector/Response Path Aging can affect homeostasis in 2 possible ways: Aging can affect homeostasis in 2 possible ways: Biological age changes to structures that allow more rapid or extreme alteration in body conditions (i.e. body temp) loss of fat in elderly loss of fat in elderly thinning of skin thinning of skin loss of sweat glands loss of sweat glands decreased # of blood vessels and blood flow to skin surface decreased # of blood vessels and blood flow to skin surface decrease in muscle mass and loss of body hair decrease in muscle mass and loss of body hair Biological age changes to negative feedback that allow more rapid or extreme alteration in body conditions (i.e. body temp) nerve cells left function weakly so response time slow nerve cells left function weakly so response time slow Nervous system changes with age Nervous system changes with age # # of nerve cells that monitor condition of nerve cells that monitor condition of receptors that detect alterations in body systems results in a decreased in detection + response results in a decreased in detection + response # #...
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This note was uploaded on 12/03/2010 for the course SCI 255 taught by Professor Duxbery during the Fall '10 term at Waterloo.

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Sci255_Lecture3-10 - BIOLOGY OF AGING LECTURE 3 BIOLOGY OF...

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