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sept29post - 1 What affects rate of enzyme-controlled rxns...

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1 9/29/10 1. What affects rate of enzyme-controlled rxns? 2. Enzyme inhibitors – allosteric or competitive 3. End-product negative feedback control 4. Index card questions . A catalyst reduces the activation barrier. A catalyst can speed up the rate of a reaction without itself being used up in the reaction. Enzymes are biological catalysts. Catalytic Cycle enzyme-substrate complex Substrate binds at the enzyme’s active site • Active site - groove or pocket - why? • Enzyme-substrate bind by multiple weak bonds • Specificity of binding depends on –Surface shape of active site –R groups at active site Energy-wise, an enzyme reduces the activation energy. But how - physically - can an enzyme reduce the activation barrier? Some ways it can happen: Enzymes facilitate binding reactants and stressing reactants to enter a transition phase – (a) orientation; (b) physical strain; (c) chemical charge
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2 What affects rates of enzyme controlled reactions?
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