DNAassembly05 - Rapid Chiral Assembly of Rigid DNA Building...

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DOI: 10.1126/science.1120367 , 1661 (2005); 310 Science et al. R. P. Goodman, Blocks for Molecular Nanofabrication Rapid Chiral Assembly of Rigid DNA Building www.sciencemag.org (this information is current as of November 2, 2009 ): The following resources related to this article are available online at http://www.sciencemag.org/cgi/content/full/310/5754/1661 version of this article at: including high-resolution figures, can be found in the online Updated information and services, http://www.sciencemag.org/cgi/content/full/310/5754/1661/DC1 can be found at: Supporting Online Material http://www.sciencemag.org/cgi/content/full/310/5754/1661#otherarticles , 6 of which can be accessed for free: cites 20 articles This article 107 article(s) on the ISI Web of Science. cited by This article has been http://www.sciencemag.org/cgi/content/full/310/5754/1661#otherarticles 7 articles hosted by HighWire Press; see: cited by This article has been http://www.sciencemag.org/cgi/collection/chemistry Chemistry : subject collections This article appears in the following http://www.sciencemag.org/about/permissions.dtl in whole or in part can be found at: this article permission to reproduce of this article or about obtaining reprints Information about obtaining registered trademark of AAAS. is a Science 2005 by the American Association for the Advancement of Science; all rights reserved. The title Copyright American Association for the Advancement of Science, 1200 New York Avenue NW, Washington, DC 20005. (print ISSN 0036-8075; online ISSN 1095-9203) is published weekly, except the last week in December, by the Science on November 2, 2009 www.sciencemag.org Downloaded from
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Slingsby, C. V. Robinson, Proc. Natl. Acad. Sci. U.S.A. 100 , 10611 (2003). 31. E. H. J. Koch, P. Vachette, D. I. Svergun, Q. Rev. Biophys. 36 , 147 (2003). 32. P. Aloy et al. , Science 303 , 2026 (2004). 33. We thank P. Gollnick for the TRAP protein complex used in these studies as well as M. Vendruscolo and M. McCammon for helpful discussions. This work is supported through the Walters-Kundert Trust and the Research Councils’ Basic Technology Programme. Supporting Online Material www.sciencemag.org/cgi/content/full/1120177/DC1 Materials and Methods SOM Text Figs. S1 to S6 Table S1 References and Notes 14 September 2005; accepted 31 October 2005 Published online 17 November 2005; 10.1126/science.1120177 Include this information when citing this paper. Rapid Chiral Assembly of Rigid DNA Building Blocks for Molecular Nanofabrication R. P. Goodman, 1 I. A. T. Schaap, 2 C. F. Tardin, 2 C. M. Erben, 1 R. M. Berry, 1 C. F. Schmidt, 2 A. J. Turberfield 1 * Practical components for three-dimensional molecular nanofabrication must be simple to produce, stereopure, rigid, and adaptable. We report a family of DNA tetrahedra, less than 10 nanometers on a side, that can self-assemble in seconds with near-quantitative yield of one diastereomer. They can be connected by programmable DNA linkers. Their triangulated architecture confers structural stability; by compressing a DNA tetrahedron with an atomic force microscope, we have measured the axial compressibility of DNA and observed the buckling of the double helix under high loads.
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