2 - VertPhysNotes9/2 12:10:00 : K ,Na levelslower Nerve/...

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Vert Phys Notes 9/2 11/09/2010 12:10:00 Bernstein’s hypothesis: resting potential is set by K+ K+ levels inside muscle higher, Na+ levels lower Nerve/muscle cells selectively permeable to K+ at rest  o Efflux k+ caused Resting Potential Squid Giant Axon o Mantle, cross-sections have nerve fibers Stellate ganglion o Giant axon convenient in that we can squeeze out intracellular fluid  and replace with fluid of choice o Giant axon’s purpose? Speed Escape (behavior is controlled) Experiment: o Extracell. K+ manipulated ( not changing charge only increase in  concentration) o Raise extracellular k+, membrane potential becomes more and more  positive o See less of an agreement with data and black line at lower  concentration (biologically relevant levels) Tells us other ions are involved Vary level of Ca 2+ and Cl-, had no effect 
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