notes-mitosis - M i tosis and cytokinesis Division of...

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Mitosis and cytokinesis Division of chromosomes in nucleus Newly divided cells go through a series of phases: G1 (gap 1), S (period of synthesis), G2 (Gap 2), M (More cell division) Most cells are G1 if they are not dividing Protein inhibits division- RB protein RB gene active in preventing division in cells throughout; if it mutates, then cell divides ex. Eye Most non-dividing cells, division is prevented by this protein If it does divide, cyclin (protein) phosphorylates the RB and turns it off The Cyclin genes has phosphate from Cyclin D S phase- duplication of DNA (2 complete copies) G2- completion of the synthesis; prepares to divide the new chromosomes M phase- first part of mitosis DNA (chromatin) is wound up into a helix into a manageable length; condensed chromosomes by multiple stages of coiling Two daughter cells- two chromatids Joined at centromere Division or separation of chromatids; not really chromosomes
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