genomics - LECTURE 8 Genomics-OMICS Genomics...

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LECTURE 8: Genomics
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- OMICS” Genomics Transcriptomics Proteomics Interactomics Regulomics Metabolomics
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Overview Milestones in Genomics Bioinformatics in Genomics Genomics & Biological Complexity Genomic Race: Towards personal genomics Genomics & Evolution Age of Genomic Expansion
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Milestones of Genomics Sanger sequences first DNA genome (virus Phi X, 11 genes; 1977) Haemophilus Influenzae sequenced (1 st organism, 1800 genes; 1995) C. elegans (first multicellular genome, 18,266 genes; 1998) Arabidopsis thaliana (first plant genome, 26,000 genes; 2000) Human genome (25,000 genes, 2001) Shotgun sequencing of the Sargasso Sea (2004) 1 st genome transplantation ( Mycoplasma mycoides to M.capricolum; 2007) 1 st Personal Genome using Sanger methods (Venter, 2007) followed by the sequencing of James D. Watson’s genome. Complete chemical synthesis of Mycoplasma genitalium genome (2008) Design, synthesis and assembly of M.mycoides genome and tranplantation into M.capricolum in which the “new” organism can self -replicate. (2010)
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Bioinformatics As of 15 August 2010 GenBank has 117,476,523,128 bases, from 122,941,883 reported sequences. According to NCBI, GenBank has doubled every 18 months since 1982.
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Human neurofibromatosis 1 gene is related to yeast Ira Knowledge about Ira informs the study of NF1.
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Hox genes and the Body plan
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