lec 6 - Regulation of prokaryotic gene expression (pp....

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Regulation of prokaryotic gene expression (pp. 271-276)
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Transcriptional control • Usually the major mechanism for controlling production of the protein encoded by a given gene. • Transcription of a gene can be repressed (little or no mRNA is synthesized) or activated (up to 1000x or more mRNA is synthesized)
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Unicellular versus multicellular organisms Single-celled organisms – Genes are regulated to adjust to changes in the nutritional and physical environment. A cell usually produces only the proteins required for survival and proliferation under the particular environmental conditions it experiences. Multicellular organisms – Genes are regulated to ensure coordination during embryonic development and tissue differentiation.
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Operons About half the genes in E. coli are organized into operons. The lac operon encodes 3 enzymes required for the catabolism of lactose. The trp operon encodes 5 enzymes required for the biosynthesis of tryptophan. Transcription of operons and isolated genes is controlled
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This note was uploaded on 12/07/2010 for the course BIO BIOL 200 taught by Professor Frogatto during the Fall '10 term at McGill.

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lec 6 - Regulation of prokaryotic gene expression (pp....

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