lec 11 - What did we learn so far Group II self-splicing...

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What did we learn so far? Group II self-splicing introns have a structure similar to that of spliceosomes. For long transcriptional units, splicing begins as the pre-mRNA is still being transcribed. Cleavage and polyadenylation occur after the poly(A) site is transcribed. Alternative splicing involves sequence-specific RNA binding proteins that can promote, or block, recognition of a splice site by components associated with the spliceosome.
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CPSF=cleavage and polyadenylation specificity factor CStF=cleavage stimulatory factor CFI, CFII=cleavage factors I and II
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Addition of the first 12 A residues occurs slowly.
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PABPII signals PAP to stop adding A residues after 200-250, but the mechanism is unknown.
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Alternative splicing controls sex determination in Drosophila
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Nucleocytoplasmic transport of macromolecules
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Nuclear pore complexes resemble baskets, and are the sites of nucleocytoplasmic transport
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The nuclear pore complex is a highly ordered structure
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Nuclear pore complex (NPC) It’s huge: 125 megadaltons or 30x bigger than a ribosome.
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