lec 30 - Lecture 30 Protein sorting/targeting Cells have...

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Lecture 30 Protein sorting/targeting
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Cells have many different compartments and proteins have to be targeted to them. red= mitochondria green= endoplasmic reticulum
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Cell compartments Golgi Extracellular space ER Secretory vesicle Lysosome Mitochondria Peroxisome Nucleus Plasma membrane Cytoplasm Red =cytoplasmic Blue = luminal/extracellular Lumen
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Two processes for protein targeting • (1) Targeting to the membrane of an intracellular organelle – Occurs during or soon after synthesis of the protein – For membrane proteins, targeting leads to insertion in the organelle membrane; for water-soluble proteins, targeting leads to translocation of the protein to the interior of the organelle. – Proteins go to the ER, mitochondria, chloroplasts, peroxisomes, and the nucleus via this process.
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• (2) Targeting to the ER for subsequent secretion. – Involves nascent proteins still being synthesized. – Proteins are transported by small vesicles. – Vesicle-based transport involves a lot of cell biology and will not be discussed in BIOL200. Two processes for protein targeting
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This note was uploaded on 12/07/2010 for the course BIO BIOL 200 taught by Professor Frogatto during the Fall '10 term at McGill.

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lec 30 - Lecture 30 Protein sorting/targeting Cells have...

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