lec 30 - Lecture 30 Protein sorting/targeting Cells have...

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Lecture 30 Protein sorting/targeting
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Cells have many different compartments and proteins have to be targeted to them. red= mitochondria green= endoplasmic reticulum
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Cell compartments Golgi Extracellular space ER Secretory vesicle Lysosome Mitochondria Peroxisome Nucleus Plasma membrane Cytoplasm Red =cytoplasmic Blue = luminal/extracellular Lumen
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Two processes for protein targeting (1) Targeting to the membrane of an intracellular organelle Occurs during or soon after synthesis of the protein For membrane proteins, targeting leads to insertion in the organelle membrane; for water-soluble proteins, targeting leads to translocation of the protein to the interior of the organelle. Proteins go to the ER, mitochondria, chloroplasts, peroxisomes, and the nucleus via this process.
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(2) Targeting to the ER for subsequent secretion. Involves nascent proteins still being synthesized. Proteins are transported by small vesicles. Vesicle-based transport involves a lot of cell biology and will not be discussed in BIOL200. Two processes for protein targeting
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Cartoon view of protein sorting pathways
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Protein targeting involves signal sequences
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