Lec3_Molecular_Evolution_of_infectious_diseases

Lec3_Molecular_Evolution_of_infectious_diseases - Molecular...

Info iconThis preview shows pages 1–9. Sign up to view the full content.

View Full Document Right Arrow Icon
Molecular Epidemiology of Infectious Diseases
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Molecular Epidemiology of ID Advances in the epidemiology of infectious diseases have always been driven by new developments in laboratory techniques. Molecular epidemiology of infectious diseases integrates the principles of molecular biology with the practice of epidemiology. The study of the distribution and determinants of infectious diseases that uses molecular biological methods.
Background image of page 2
Molecular Epidemiology of ID The practical goals of molecular epidemiology of infectious diseases are to: identify the microparasites responsible for infectious diseases and determine their physical sources, biological relationships, routes of transmission and those of the genes that are responsible for their virulence, vaccine-relevant antigens and drug resistance.
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Molecular Epidemiology of ID Riley, LW. Molecular Epidemiology of Infectious Diseases
Background image of page 4
Molecular Epidemiology of ID Important definitions: – Isolate A population of microbial cells in pure culture derived from a single colony on an isolation plate and identified to the species level Strain An isolate or group of isolates exhibiting phenotypic and/or genotypic characteristics belonging to the same lineage, distinct from other isolates of the same species – Clone An isolate or group of isolates descending from a common precursor strain by nonsexual reproduction exhibiting genotypic or phenotypic traits characterized by a strain-typing method to belong to the same group – Type A specific and discrete unit of information or character belonging to a strain displayed upon application of a strain-typing procedure Discriminatory Power The ability of a test to generate distinct and discrete units of information from different isolates, usually at a subspecies level
Background image of page 5

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Laboratory Tools for Bacterial Pathogens When speaking of the following methods, they are all ways to strain-type an organism. There are 5 performance criteria that have been proposed to evaluate strain-typing systems: Typeability The ability of a technique to generate unambiguous results for an isolate tested. Reproducibility (Reliability) The ability of a test to produce identical results when a strain is tested repeatedly. Discriminatory Power Ease of Interpretation Ease of Use
Background image of page 6
Molecular Epidemiology of ID Riley, LW. Molecular Epidemiology of Infectious Diseases
Background image of page 7

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Laboratory Tools for Bacterial Pathogens There are a number of conventional (non-molecular) techniques that are very useful. Biotyping
Background image of page 8
Image of page 9
This is the end of the preview. Sign up to access the rest of the document.

Page1 / 30

Lec3_Molecular_Evolution_of_infectious_diseases - Molecular...

This preview shows document pages 1 - 9. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online