Lec3_Molecular_Evolution_of_infectious_diseases

Lec3_Molecular_Evolution_of_infectious_diseases - Molecular...

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Molecular Epidemiology of Infectious Diseases
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Molecular Epidemiology of ID Advances in the epidemiology of infectious diseases have always been driven by new developments in laboratory techniques. Molecular epidemiology of infectious diseases integrates the principles of molecular biology with the practice of epidemiology. The study of the distribution and determinants of infectious diseases that uses molecular biological methods.
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Molecular Epidemiology of ID The practical goals of molecular epidemiology of infectious diseases are to: identify the microparasites responsible for infectious diseases and determine their physical sources, biological relationships, routes of transmission and those of the genes that are responsible for their virulence, vaccine-relevant antigens and drug resistance.
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Molecular Epidemiology of ID Riley, LW. Molecular Epidemiology of Infectious Diseases
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Molecular Epidemiology of ID Important definitions: Isolate A population of microbial cells in pure culture derived from a single colony on an isolation plate and identified to the species level Strain An isolate or group of isolates exhibiting phenotypic and/or genotypic characteristics belonging to the same lineage, distinct from other isolates of the same species Clone An isolate or group of isolates descending from a common precursor strain by nonsexual reproduction exhibiting genotypic or phenotypic traits characterized by a strain-typing method to belong to the same group Type A specific and discrete unit of information or character belonging to a strain displayed upon application of a strain-typing procedure Discriminatory Power The ability of a test to generate distinct and discrete units of information from different isolates, usually at a subspecies level
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Laboratory Tools for Bacterial Pathogens When speaking of the following methods, they are all ways to strain-type an organism. There are 5 performance criteria that have been proposed to evaluate strain-typing systems: Typeability The ability of a technique to generate unambiguous results for an isolate tested. Reproducibility (Reliability) The ability of a test to produce identical results when a strain is tested repeatedly. Discriminatory Power Ease of Interpretation Ease of Use
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Molecular Epidemiology of ID Riley, LW. Molecular Epidemiology of Infectious Diseases
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Laboratory Tools for Bacterial Pathogens There are a number of conventional (non-molecular) techniques that are very useful.
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