Lec9_Measles

Lec9_Measles - Measles Measles Measles also known as...

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Measles
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Measles Measles, also known as rubeola, is a highly contagious viral disease, which affects mostly children. Measles is one of the leading causes of death among young children even though a safe and cost-effective vaccine is available. In developing countries, 1-5% of children with measles die from complications of the disease. This case-fatality rate may be as high as 25% among people who are displaced, malnourished and have poor access to health care.
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Measles Family: Paramyxoviridae Genus: Morbillivirus Spherical Single-stranded, negative sense RNA virus
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Measles Source: CDC PHIL
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Measles Virus Budding from the Cell
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Measles Basic Phylogenetic Tree
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Measles Antigenically stable Major proteins Hemagglutinin (H): receptor binding protein Fusion (F): membrane fusion and virus entry Nucleoprotein (N): most variable genetically Sensitive to UV light and heat
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Measles Pathogenesis Measles is transmitted through respiratory droplets. Infectious virus is carried to the epithelial cells of the respiratory tract of a susceptible host. The incubation period is approximately 10-14 days, during which the virus replicates and spreads within the infected host. Initial virus replication occurs in epithelial cells at the point of entry in the upper respiratory tract.
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Measles Pathogenesis From the respiratory epithelium the virus spreads to the regional lymphatics. A primary viremia then occurs, in which the virus replicates at the site of inoculation and in the reticuloendothelial tissues. A secondary viremia follows, in which the virus infects and replicates in the skin, conjunctiva, respiratory tract, and other distant organs.
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Measles Pathogenesis The measles rash is thought to be due to a hypersensitivity reaction. Cell-mediated responses are the main line of defense against measles, as evidenced by the fact that people with cell-mediated deficiencies develop severe measles infection. Immunity to wild-type measles is believed to be lifelong.
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Clinical Features of Measles
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Clinical Features of Measles Source: CDC PHIL
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Clinical Features of Measles Source: CDC PHIL
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Clinical Features of Measles Source: Perry RT, et al. The Clinical Significance of Measles: A Review.
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Clinical Features of Measles Source: CDC PHIL
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Clinical Features of Measles Source: William Moss
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Clinical Features of Measles Source: CDC PHIL
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In uncomplicated measles, clinical recovery begins soon after the appearance of the rash. Complications occur in up to 40% of measles cases. The risk of complications is increased by the extremes of age and malnutrition. Complications of measles have been described in almost every organ system. Many of these complications are caused by
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This note was uploaded on 12/07/2010 for the course EPI 220 taught by Professor A during the Fall '10 term at UCLA.

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Lec9_Measles - Measles Measles Measles also known as...

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