Lecture5_Rearrangements - An Introduction to Bioinformatics...

Info icon This preview shows pages 1–16. Sign up to view the full content.

View Full Document Right Arrow Icon
www.bioalgorithms.info An Introduction to Bioinformatics Algorithms Greedy Algorithms And Genome Rearrangements
Image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
An Introduction to Bioinformatics Algorithms www.bioalgorithms.info Outline Transforming Cabbage into Turnip Genome Rearrangements Sorting By Reversals Pancake Flipping Problem Greedy Algorithm for Sorting by Reversals Approximation Algorithms Breakpoints: a Different Face of Greed Breakpoint Graphs
Image of page 2
An Introduction to Bioinformatics Algorithms www.bioalgorithms.info Turnip vs Cabbage: Look and Taste Different Although cabbages and turnips share a recent common ancestor, they look and taste different
Image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
An Introduction to Bioinformatics Algorithms www.bioalgorithms.info Turnip vs Cabbage: Comparing Gene Sequences Yields No Evolutionary Information
Image of page 4
An Introduction to Bioinformatics Algorithms www.bioalgorithms.info Turnip vs Cabbage: Almost Identical mtDNA gene sequences In 1980s Jeffrey Palmer studied evolution of plant organelles by comparing mitochondrial genomes of the cabbage and turnip 99% similarity between genes These surprisingly identical gene sequences differed in gene order This study helped pave the way to analyzing genome rearrangements in molecular evolution
Image of page 5

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
An Introduction to Bioinformatics Algorithms www.bioalgorithms.info Turnip vs Cabbage: Different mtDNA Gene Order Gene order comparison:
Image of page 6
An Introduction to Bioinformatics Algorithms www.bioalgorithms.info Turnip vs Cabbage: Different mtDNA Gene Order Gene order comparison:
Image of page 7

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
An Introduction to Bioinformatics Algorithms www.bioalgorithms.info Turnip vs Cabbage: Different mtDNA Gene Order Gene order comparison:
Image of page 8
An Introduction to Bioinformatics Algorithms www.bioalgorithms.info Turnip vs Cabbage: Different mtDNA Gene Order Gene order comparison:
Image of page 9

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
An Introduction to Bioinformatics Algorithms www.bioalgorithms.info Turnip vs Cabbage: Different mtDNA Gene Order Gene order comparison: Befor e After Evolution is manifested as the divergence in gene order
Image of page 10
An Introduction to Bioinformatics Algorithms www.bioalgorithms.info Transforming Cabbage into Turnip
Image of page 11

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
An Introduction to Bioinformatics Algorithms www.bioalgorithms.info What are the similarity blocks and how to find them? What is the architecture of the ancestral genome? What is the evolutionary scenario for transforming one genome into the other? Unknown ancestor ~ 75 million years ago Mouse (X chrom.) Human (X chrom.) Genome rearrangements
Image of page 12
An Introduction to Bioinformatics Algorithms www.bioalgorithms.info History of Chromosome X Rat Consortium, Nature , 2004
Image of page 13

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
An Introduction to Bioinformatics Algorithms www.bioalgorithms.info Reversals Blocks represent conserved genes. 1 3 2 4 10 5 6 8 9 7 1, 2, 3, 4, 5, 6, 7, 8, 9, 10
Image of page 14
An Introduction to Bioinformatics Algorithms www.bioalgorithms.info Reversals 1 3 2 4 10 5 6 8 9 7 1, 2, 3, -8, -7, -6, -5, -4, 9, 10 Blocks represent conserved genes.
Image of page 15

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Image of page 16
This is the end of the preview. Sign up to access the rest of the document.

{[ snackBarMessage ]}

What students are saying

  • Left Quote Icon

    As a current student on this bumpy collegiate pathway, I stumbled upon Course Hero, where I can find study resources for nearly all my courses, get online help from tutors 24/7, and even share my old projects, papers, and lecture notes with other students.

    Student Picture

    Kiran Temple University Fox School of Business ‘17, Course Hero Intern

  • Left Quote Icon

    I cannot even describe how much Course Hero helped me this summer. It’s truly become something I can always rely on and help me. In the end, I was not only able to survive summer classes, but I was able to thrive thanks to Course Hero.

    Student Picture

    Dana University of Pennsylvania ‘17, Course Hero Intern

  • Left Quote Icon

    The ability to access any university’s resources through Course Hero proved invaluable in my case. I was behind on Tulane coursework and actually used UCLA’s materials to help me move forward and get everything together on time.

    Student Picture

    Jill Tulane University ‘16, Course Hero Intern