Translation concepts 10.11 - amino acids attached to the...

Info icon This preview shows pages 1–2. Sign up to view the full content.

View Full Document Right Arrow Icon
Clicker: The human dystophin gene contains 2.4 million base pairs with 79 exons, while the final (mature) mRNA transcribed from this gene is 14,000 base pairs. What percentage of the DNA is this gene actually codes for the protein? .5% Genetic Code mRNA nucleotides Triplet Cide Degenerate or redundant code rRNA and tRNA involbved in this process rRNA as part of the ribosome (site of protein synthesis) tRNA anti-codon and an amino acid TRANSLA TION: initiation : 5' end of mRNA binds to the small ribosomal subunit and the first codon (AUG) (always the first codon) pairs with a tRNA with the anticodon to AUG this tRNA carries the amino acid methionine. The large subunit now binds to form a functional ribosome (P site) Figure 17.17 chain elongation : the ribosome can bind 2 tRNAs (each with 1 amino acid). One in the P (peptidyl) site and the other in the A (aminoacyl) site. Peptide bonds form between the
Image of page 1

Info icon This preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Image of page 2
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: amino acids attached to the tRNAs and the tRNA in the P site is released. ribosome moves 3 nucleotides at a time About making the polypeptide chain; taking amino acids and joining them together; have a second tRNA through the A site, have the anti-codon and another amino acid; (Figure 17.18) A site, P site, E site; Moves 3 nucleotides at a time; termination message : when ribosome reaches a stop codon (UAA, UAG, UGA) the newly formed polypeptide is released. (Figure 17.19) Insert releasing factor: 1. break the body between molecule so polypeptide chain is free 2. 3. break the molecule apart PKU is caused by the lack of functional phenylalanine hydroxylase enzyme. Phenylalanine hydroxylase is 452 amino acids long and several different mutations have been discovered. MUT A TION Point Mutations : Base substitutions: Frame shift mutations: Chromosomal Mutations:...
View Full Document

{[ snackBarMessage ]}

What students are saying

  • Left Quote Icon

    As a current student on this bumpy collegiate pathway, I stumbled upon Course Hero, where I can find study resources for nearly all my courses, get online help from tutors 24/7, and even share my old projects, papers, and lecture notes with other students.

    Student Picture

    Kiran Temple University Fox School of Business ‘17, Course Hero Intern

  • Left Quote Icon

    I cannot even describe how much Course Hero helped me this summer. It’s truly become something I can always rely on and help me. In the end, I was not only able to survive summer classes, but I was able to thrive thanks to Course Hero.

    Student Picture

    Dana University of Pennsylvania ‘17, Course Hero Intern

  • Left Quote Icon

    The ability to access any university’s resources through Course Hero proved invaluable in my case. I was behind on Tulane coursework and actually used UCLA’s materials to help me move forward and get everything together on time.

    Student Picture

    Jill Tulane University ‘16, Course Hero Intern