BIPN140 Lecture 13-1 - Lecture 13 BIPN140 Early Brain...

Info icon This preview shows pages 1–2. Sign up to view the full content.

Lecture 13 November 16, 2010 BIPN140 Reading: Chapter 22 Early Brain Development 1. The Events of Development - overview Induction/determination, proliferation, migration, differentiation of excitability, development of neurotransmitter synthesis , axon elongation, dendrite outgrowth, synapse formation, synaptic rearrangement, cell death. Discuss underlined items today. The rest are covered in the next lecture. 2. Induction: setting up the body plan/organizing tissues and cells -Fertilization>blastula>gastrula -Formation of notochord -Mesoderm>ectoderm signaling=primary induction -The neural plate>neural groove>neural tube. Neural crest, from the ridges of the neural groove -Roofplate, floorplate, notochord, somites: sources of inductive signals -Neural precursor cells: progenitor cells of neural tube/stem cells -Neuroblasts: post-mitotic/not dividing/differentiate into neurons 3. Induction: the molecular basis -Overview: ligands bind receptors that signal to the nucleus and alter gene transcription -Retinoic acid -BMPs -Shh -BMPs elicit bone formation (osteogenesis) from ectoderm. This is prevented in the
Image of page 1

Info icon This preview has intentionally blurred sections. Sign up to view the full version.

Image of page 2
This is the end of the preview. Sign up to access the rest of the document.

{[ snackBarMessage ]}

What students are saying

  • Left Quote Icon

    As a current student on this bumpy collegiate pathway, I stumbled upon Course Hero, where I can find study resources for nearly all my courses, get online help from tutors 24/7, and even share my old projects, papers, and lecture notes with other students.

    Student Picture

    Kiran Temple University Fox School of Business ‘17, Course Hero Intern

  • Left Quote Icon

    I cannot even describe how much Course Hero helped me this summer. It’s truly become something I can always rely on and help me. In the end, I was not only able to survive summer classes, but I was able to thrive thanks to Course Hero.

    Student Picture

    Dana University of Pennsylvania ‘17, Course Hero Intern

  • Left Quote Icon

    The ability to access any university’s resources through Course Hero proved invaluable in my case. I was behind on Tulane coursework and actually used UCLA’s materials to help me move forward and get everything together on time.

    Student Picture

    Jill Tulane University ‘16, Course Hero Intern