BIPN140 Lecture 13-1 - Lecture 13 BIPN140 Early Brain...

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Lecture 13 November 16, 2010 BIPN140 Reading: Chapter 22 Early Brain Development 1. The Events of Development - overview Induction/determination, proliferation, migration, differentiation of excitability, development of neurotransmitter synthesis , axon elongation, dendrite outgrowth, synapse formation, synaptic rearrangement, cell death. Discuss underlined items today. The rest are covered in the next lecture. 2. Induction: setting up the body plan/organizing tissues and cells -Fertilization>blastula>gastrula -Formation of notochord -Mesoderm>ectoderm signaling=primary induction -The neural plate>neural groove>neural tube. Neural crest, from the ridges of the neural groove -Roofplate, floorplate, notochord, somites: sources of inductive signals -Neural precursor cells: progenitor cells of neural tube/stem cells -Neuroblasts: post-mitotic/not dividing/differentiate into neurons 3. Induction: the molecular basis -Overview: ligands bind receptors that signal to the nucleus and alter gene transcription -Retinoic acid -BMPs -Shh -BMPs elicit bone formation (osteogenesis) from ectoderm. This is prevented in the
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