Bipn140 Lect 12 Notes Nov10

Bipn140 Lect 12 Notes Nov10 - BIPN 140 LECT #12 1 DKBerg...

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BIPN 140 LECT #12 1 DKBerg SYNAPTIC PLASTICITY II I. Molecular Mechanisms of LTP (cont’d) A. Review 1. Postsyn calcium requirement 2. NMDA receptors 3. CaMKII **FIGURE 8.11**. B. Recruitment of AMPA receptors 1. LTP (at CA3 syns onto CA1) – rapid recruitment of pre-existing AMPA receptors to the synapse Diag: * * F I G U R E 8 . 1 2 a / c * * . 2. Roles of AMPA Receptor Subtypes (heteromers w 4 subs) a) GluR1-containing receptors (lacking GluR2) - appear early in development - have high relative calcium permeability - undergo activity-dependent insertion into postsynaptic membrane; serve as “place holders” b) GluR2-containing receptors - appear later in development - have low calcium permeability (when RNA edited) - undergo constituitive insertion into synapses, replacing GluR1s Diag: C. Role of protein synthesis in LTP
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BIPN 140 LECT #12 2 DKBerg 1. Late phase (after 3 hrs): blocked by protein syn inhibitors 2. Structural changes: new spines in some cases **FIGURE 13**. **FIGURE 14a-c**. II. Silent Synapses – evidence for LTP model A. Historical: Key in “Pre vs Post” model for site of LTP at syn B. Concept: Postsyn NMDA R’s but no AMPA R’s; no EPSP (early
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This note was uploaded on 12/09/2010 for the course BIPN BIPN 140 taught by Professor Spitzer during the Spring '07 term at UCSD.

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Bipn140 Lect 12 Notes Nov10 - BIPN 140 LECT #12 1 DKBerg...

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