BIPN 140 Lecture 17 11.23.10 - BIPN 140 Lecture 17 Podcast...

Info icon This preview shows pages 1–2. Sign up to view the full content.

View Full Document Right Arrow Icon
BIPN 140 Lecture 17 Podcast 11.23.10 Lecture 15 on slides Final Exam: Friday, De 10, 7-10pm, 107 Solis (here) Review Session: Thurs, Dec 9, 7-9pm, 3500 Pac Hall SYNAPSE FORMATION (Outline with added comments) I. Synaptic Structural Complexity - examples A. Vertebrate Neuromuscular Junction (NMJ) (Large Synapse) (Post synaptive folds with presynaptic vesicles) (10^4 receptors almost crystalline packed) (Pre synaptic site) Sketch: B. Glutamatergic Spine Synapses in the CNS **FIGURE: EM image of NMJ** **Box 7Bb-e **. (presynaptic with vesicles) (post synaptic with f actin forming the spine) II. NMJ Development – original model system A. Morphological Features 1. Initial contact ----() 2. Multiple synapses – several cholinergic synapses ====() 3. Monosynaptic – mediated by competition back to the -----() 4. Maturation: infolding, basal lamina, Schwann cells Slide 2 NMJ active zone of frog Slide 3 cartoon of glutamate synapse; presynaptic gluton, mitochondria Slide 4 Dendritic Spines (100s have been identified in spines) **FIGURE 23.10** **FIGURE 23.11**. III. Regulation of Postsynaptic nAChRs at the NMJ - Numbers A. Role of Activity 1. Denervation (cut the nerve) produces increase in (receptors outside the synapse) extrajunctional nAChRs (just like what is seen in embryonic conditions) Sketch: den & fetal muscle: 2. Test: stimulate denervated muscle – retains innervated nAChR distribution. Conclude: activity controls the distribution of the Ach receptor on the muscle (podcast 23:00-25:00)3. Mechanism: -Ach decrease AChR synthesis and causes increase to AChr internalization -activity reduces extrajunctional nAChR synthesis (turnsover rapidly; lost); stabilizes junctional (turns over slowly; retained). B. Role of Trophic Factors – Neuregulin (only where nerve terminal is)(ARIA)(acetyl choline receptor IA) 1. Source: Motorneuron secretes it 2. Actions: Binds to ErbB receptors on muscle increases nAChR synthesis IV. Regulation of NMJ nAChR Distribution A. Nerve Effects (in culture) 1. nerve induces nAChR clusters 2. nerve can redistributes existing clusters to nerve sites Sketch: had tube in a cultured dish; here is a nerve going in; you would see fluorescent clusters and you let it go a few hours; as the nerve grows the myotube has nerve zig zag across and the
Image of page 1

Info icon This preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Image of page 2
This is the end of the preview. Sign up to access the rest of the document.

{[ snackBarMessage ]}

What students are saying

  • Left Quote Icon

    As a current student on this bumpy collegiate pathway, I stumbled upon Course Hero, where I can find study resources for nearly all my courses, get online help from tutors 24/7, and even share my old projects, papers, and lecture notes with other students.

    Student Picture

    Kiran Temple University Fox School of Business ‘17, Course Hero Intern

  • Left Quote Icon

    I cannot even describe how much Course Hero helped me this summer. It’s truly become something I can always rely on and help me. In the end, I was not only able to survive summer classes, but I was able to thrive thanks to Course Hero.

    Student Picture

    Dana University of Pennsylvania ‘17, Course Hero Intern

  • Left Quote Icon

    The ability to access any university’s resources through Course Hero proved invaluable in my case. I was behind on Tulane coursework and actually used UCLA’s materials to help me move forward and get everything together on time.

    Student Picture

    Jill Tulane University ‘16, Course Hero Intern