BIPN 140 11.18.10

BIPN 140 11.18.10 - BIPN 140 November 18, 2010 Thursday...

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BIPN 140 November 18, 2010 Thursday 5-6:20pm 1. Events of development -axon (dendrite) outgrowth -cell survival & cell death -synapse elimination 2. Making the right connections a. 10^11 neurons, 10^3 synapses/neuron (10^14 synapses that have to be made) b. the brain is not assembled like a computer Rule #1 Brain is assembled by intrinsic devel. Mechanisms -brain self-assembles 3. Growth Cones: Cell body ------axon---------< the < is the growth cone structure Important for dual functions: -directed growth -target recognition 1 st described by Cajal – fixed stained tissues work Hamson 1910-invented tissue culture studied g.c.’s in culture Simple morphology ---------( )- looked like streamlined bullet When g.c. had to make a decision we would see a complex morphology like the axon above B.lamellipodium the palm of the growth cone < above (looks like a hand) C. Components -microtubules in the lamellipodeum -actin microfilaments- filipodia -adhesion molecules -transductino receptors (as it moves through the environment)
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This note was uploaded on 12/09/2010 for the course BIPN BIPN 140 taught by Professor Spitzer during the Spring '07 term at UCSD.

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BIPN 140 11.18.10 - BIPN 140 November 18, 2010 Thursday...

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