BIPN 140 11.18.10 - BIPN 140 Thursday 5-6:20pm Axon...

Info icon This preview shows pages 1–2. Sign up to view the full content.

View Full Document Right Arrow Icon
BIPN 140 November 18, 2010 Thursday 5-6:20pm Axon Guidance Guidance & Target Selection 1. Events of development -axon (dendrite) outgrowth -cell survival & cell death -synapse elimination 2. Making the right connections a. 10^11 neurons, 10^3 synapses/neuron (10^14 synapses that have to be made) b. the brain is not assembled like a computer Rule #1 Brain is assembled by intrinsic devel. Mechanisms -brain self-assembles 3. Growth Cones: Cell body ------axon---------< the < is the growth cone structure Important for dual functions: -directed growth -target recognition 1 st described by Cajal – fixed stained tissues work Hamson 1910-invented tissue culture studied g.c.’s in culture Simple morphology ---------( )- looked like streamlined bullet When g.c. had to make a decision we would see a complex morphology like the axon above B.lamellipodium the palm of the growth cone < above (looks like a hand) C. Components -microtubules in the lamellipodeum -actin microfilaments- filipodia -adhesion molecules -transductino receptors (as it moves through the environment)
Image of page 1

Info icon This preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Image of page 2
This is the end of the preview. Sign up to access the rest of the document.

{[ snackBarMessage ]}

What students are saying

  • Left Quote Icon

    As a current student on this bumpy collegiate pathway, I stumbled upon Course Hero, where I can find study resources for nearly all my courses, get online help from tutors 24/7, and even share my old projects, papers, and lecture notes with other students.

    Student Picture

    Kiran Temple University Fox School of Business ‘17, Course Hero Intern

  • Left Quote Icon

    I cannot even describe how much Course Hero helped me this summer. It’s truly become something I can always rely on and help me. In the end, I was not only able to survive summer classes, but I was able to thrive thanks to Course Hero.

    Student Picture

    Dana University of Pennsylvania ‘17, Course Hero Intern

  • Left Quote Icon

    The ability to access any university’s resources through Course Hero proved invaluable in my case. I was behind on Tulane coursework and actually used UCLA’s materials to help me move forward and get everything together on time.

    Student Picture

    Jill Tulane University ‘16, Course Hero Intern