Bipn140 Lect 11 Notes Nov10

Bipn140 Lect 11 Notes Nov10 - BIPN 140 LECT #11 1 DKBerg...

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BIPN 140 LECT #11 1 DKBerg SYNAPTIC PLASTICITY I I. Short-Term Synaptic Plasticity A. Types 1. Synaptic facilitiation – msecs; results from calcium pile-up due to quick succession APs 2. Synaptic depression – ms-sec; results from transient depletion of readily releasable SV pool 3. Synaptic augmentation – secs; more effective use of calcium (munc-13 reg?) 4. Post-tetanic potentiation (PTP) –secs-mins; results from better mobilization of SV pools (greater phos-synapsin to mobilize SVs?) **FIGURE 8.1a-e**. B. Coincident forms of short-term plasticity - NMJ facilitation – augmentation – depression – PTP Diag NMJ : **FIGURE 8.2**. C. Paired-Pulse Ratio (PPR) 1. Forms: paired-pulse facilitation; paired-pulse-depression 2. Dependence on AP frequency: Diag: 3. Significance/interpretation: II. Hippocampal Long-Term Potentiation (LTP)
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BIPN 140 LECT #11 2 DKBerg A. Hippcampus – structure (perforant path from entorhinal; granule cells of dentate projecting mossy fibers to CA3 pyramidals which project Schaffer collaterals to CA1 pyramidals which project out of hipp) **FIGURE 8.6**. B. LTP
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This note was uploaded on 12/09/2010 for the course BIPN BIPN 140 taught by Professor Spitzer during the Spring '07 term at UCSD.

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Bipn140 Lect 11 Notes Nov10 - BIPN 140 LECT #11 1 DKBerg...

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