Prob Set 5 - Problem Set 5 Cellular Neurobiology Fall 2010...

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1 Problem Set 5 Cellular Neurobiology Fall 2010 1. Calcium is an important second messenger used in a variety of intracellular pathways. a. What are the 4 methods a cell uses to increase intracellular levels of Ca? How do each of these methods work? b. What are the 4 methods a cell uses to remove calcium from the cytoplasm? How do these methods work? 2. Dendritic spines act as “Ca bottles”, largely confining the entering Ca to the spine interior. However, charge transfer generated by ions entering through the postsynaptic ligand-gated ion channels transfer very quickly from the spine into the dendritic shaft to add with currents from other spines. What accounts for the apparent discrepancy in outcomes? 3. GABA synapses are the primary inhibitory synapses in the brain. a. Phenobarbital prolongs each individual open state for a GABA receptor, while picrotoxin acts as a non‐competitive inhibitor of GABA channels. Draw current‐vs‐time plots for the effects of these 2 drugs compared to a standard GABA response.
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