Prob Set 5 - Problem Set 5 Cellular Neurobiology Fall 2010...

Info iconThis preview shows pages 1–2. Sign up to view the full content.

View Full Document Right Arrow Icon
1 Problem Set 5 Cellular Neurobiology Fall 2010 1. Calcium is an important second messenger used in a variety of intracellular pathways. a. What are the 4 methods a cell uses to increase intracellular levels of Ca? How do each of these methods work? b. What are the 4 methods a cell uses to remove calcium from the cytoplasm? How do these methods work? 2. Dendritic spines act as “Ca bottles”, largely confining the entering Ca to the spine interior. However, charge transfer generated by ions entering through the postsynaptic ligand-gated ion channels transfer very quickly from the spine into the dendritic shaft to add with currents from other spines. What accounts for the apparent discrepancy in outcomes? 3. GABA synapses are the primary inhibitory synapses in the brain. a. Phenobarbital prolongs each individual open state for a GABA receptor, while picrotoxin acts as a non‐competitive inhibitor of GABA channels. Draw current‐vs‐time plots for the effects of these 2 drugs compared to a standard GABA response.
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Image of page 2
This is the end of the preview. Sign up to access the rest of the document.

This note was uploaded on 12/09/2010 for the course BIPN BIPN 140 taught by Professor Spitzer during the Spring '07 term at UCSD.

Page1 / 2

Prob Set 5 - Problem Set 5 Cellular Neurobiology Fall 2010...

This preview shows document pages 1 - 2. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online