Prob Set 4 - Problem Set 4 Cellular Neurobiology Fall 2010...

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1 Problem Set 4 Cellular Neurobiology Fall 2010 1. Explain the differences in the synthesis and axoplasmic transport of small-molecule neurotransmitters versus peptide neurotransmitters. 2. Are EPPs an all-or-nothing event like action potentials or are they graded events? Explain. How was this feature of EPPs identified? 3. Lambert-Eaton myasthenic syndrome is a condition in which patients have high concentrations of antibodies against Ca ++ channels in the presynaptic terminal of motor neurons that affect affect their normal functioning. What symptoms would you expect patients of LEM to present? Explain the molecular mechanism for the symptoms. 4. Describe the steps of an experiment demonstrating that local recycling of exoctyosed synaptic vesicles occurs at presynaptic terminals. 5. Describe the molecular mechanisms of synaptic vesicle release, starting and ending at the stage where vesicles are in the reserve pool.
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