bipn 140 lecture 2 9.28.10

bipn 140 lecture 2 9.28.10 - Bipn140Lecture29.28.10...

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Bipn 140 Lecture2 9.28.10 Reading Chapter 2 Electrical signalling 1. Signal recorded depend on the method. Galvanic + Volta: 1st to understand but electricity 1791 figure 2 in notes wwith EC recording of AP nno recording of Resting Potential R.P. 3. IC (Intercellular) recording of AP figure 3 in notes BBernstein thought resting potential was  at 0 but was wrong resting potential was later found out to be -40mV II. Resting Potential There are three conditions to be met: 1. Intracellular imperveant anions - porteins 2. Selectively permeable to K+ 3. Asymmetry of permeant cations - K+ ions figure 4 in notes build up a higher concentration of K+ inside the cell with a small number of Na+ ions inside the cell All the 3 above conditions will set up the equilibrium potential.  Resting Potenital = RT/ZF *ln(K+)o/(K+)i Nernst equation (above) ccan also work for calcium and other ions Resting Potential is not as as simple as Nernst Eqn stipulates Figure 5 in notes shows observed graph Complete description of the Respting Potential provided by the Goldman /Hodgin/Katz Equation GHK equation in notes At low voltages the MB voltage potential will push some ions back into the cell so observed 
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This note was uploaded on 12/09/2010 for the course BIPN BIPN 140 taught by Professor Spitzer during the Spring '07 term at UCSD.

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bipn 140 lecture 2 9.28.10 - Bipn140Lecture29.28.10...

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