Bio lecture 8 - Lecture 8 Guide September 11 See EXAM 1...

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Lecture 8 Guide September 11 See EXAM 1 READINGS, Chapter 5 and 6 (Moodle) Protein Structure and Shape (Fig 5.21, continued from Lecture 7) Importance of protein shape to function Example (see Fig. 5.22): Primary structure- amino acid sequence (determined by genetic code, see Fig. 5.21); Covalent bonds Secondary structure – hydrogen bonds at the backbone level Tertiary Structure – shape produced by bonds between side chains - Hydrogen bonds - Hydrophobic interactions - Disulfide bonds - Ionic bonds Quaternary Structure – aggregation of polypeptides Protein Shape Controls Function – Ex. Loss of hemoglobin function and sickle-cell disease One amino acid change, Denaturation - Altered environment changes bonds, protein shape
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(see Fig. 5.23) ethanol Nucleic Acids 1.Store/transfer genetic information for protein synthesis: a. Deoxyribonucleic acid (DNA) b. Ribonucleic acid (RNA) 2. Nucleic acids: polymers of nucleotides Protein Synthesis (Fig. 5.26) RNA Protein Transcription –nucleus of eukaryotes Translation – cytoplasm of eukaryotes
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