November 9

November 9 - Biology 442 Developmental Biology Lecture 6...

Info iconThis preview shows pages 1–10. Sign up to view the full content.

View Full Document Right Arrow Icon
Biology 442 Developmental Biology Lecture 6 Neurulation and Neural Crest
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Lecture outline I. Neurulation Mechanisms of primary neurulation: -Formation and shaping of the neural plate/ Bending of the neural plate/ Closure of the neural groove - Forces that drive primary neurulation Mechanisms of secondary neurulation Folic acid and neural birth defetcs II. Neural crest Neural crest specification Neural crest migration
Background image of page 2
Learning goals for this class Name and describe the key events that shape the neural tube during primary neurulation Compare and contrast mechanisms of primary and secondary neurulation Describe how neural crest emigrates from the neural tube during neurulation Name neural crest derivatives Explain what mechanisms are in place to regulate neural crest migration in specific pathways
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Organogenesis Case study: the brain Induction Patterning Morphogenesi s (Neurulation) Wiring Growth
Background image of page 4
The neural tube is shaped during primary and secondary neurulation Primary Secondary (Head and trunk) (Caudal region) Epithelium Bending Closure Mesenchyme Condensation Cavitation Lowery and Sive (2004). Mech Dev. 121(10):1189-97
Background image of page 5

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Failure to undergo proper neurulation results in neural tube birth defects www.nlm.nih.gov/. ../ency/imagepages/19087.ht m On the most frequent neural tube birth defects is spina bifida (1 to 2 out of 1000 newborns) Spina bifida develops during the first month after conception: - Failure of neural tube closure in the posterior region of the spinal cord - Bone and muscle cannot grow around the incompletely developed area and the cord. Meninges (membranes that cover the cord) may herniate through the resulting gap. - Spinal nerve damage can occur as a result of Spina bifida. As a consequence, paralysis of the lower extremities can occur. In addition, patients exhibit bladder and bowel problems.
Background image of page 6
Stages of primary neurulation (chick embryo) Stages: 1. Formation and shaping of the neural plate 2. Bending of the neural plate 3. Closure of the neural groove Neural ectoderm or neural plate Non neural ectoderm Neural fold Neural groove Lateral neural hinge Medial neural hinge Epidermis (skin) Neural tube (CNS) Neural crest
Background image of page 7

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Embryonic Axes M A P Anterior-posterior (A-P): head to tail Medio-lateral (M-L) becomes dorso-ventral (D-V) once neurulation is complete Narrowing of the M-L axis results in lengthening along the A-P axis
Background image of page 8
Formation and shaping of the neural plate Formation of the neural plate : apicobasal thickening of the neural plate (red arrow) relative to the non neural ectoderm. Apical
Background image of page 9

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Image of page 10
This is the end of the preview. Sign up to access the rest of the document.

Page1 / 30

November 9 - Biology 442 Developmental Biology Lecture 6...

This preview shows document pages 1 - 10. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online