October28

October28 - Biology 442 Developmental Biology Lecture 3...

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Unformatted text preview: Biology 442 Developmental Biology Lecture 3 Dorso-ventral Pattern Formation in the Drosophila Embryo Learning objectives for this class Describe how the D-V axis is organized in Drosophila Organize the different events involved in D-V patterning in sequential order and name the main genes implicated Predict how loss of D-V patterning genes perturbs D-V axis patterning Explain how cell transplantation experiments can be used to identify the cells in which a particular gene product is required. Explain how a nuclear gradient of Dorsal is interpreted by target genes Dorso-ventral Patterning in Drosophila From ventral to dorsal:- Mesoderm - Neurectoderm- Lateral ectoderm- Dorsal ectoderm- Amnioserosa How are these different tissues specified ? Involves the establishment of a D-V gradient of Dorsal nuclear localization during the syncytial blastoderm stage- ventral nuclei: high levels of Dorsal- dorsal nuclei: low levels of Dorsal Dorsal starts out uniformly expressed in the cytoplasm throughout the embryo. Upon activation in ventral regions, it translocates to the nucleus of ventral and ventro-lateral cells only Dorsal is a transcription factor that specifies ventral cell fates How are dorsal fates initially specified ?...
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October28 - Biology 442 Developmental Biology Lecture 3...

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