October28 - Biology 442 Developmental Biology Lecture 3...

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Biology 442 Developmental Biology Lecture 3 Dorso-ventral Pattern Formation in the Drosophila Embryo
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Learning objectives for this class Describe how the D-V axis is organized in Drosophila Organize the different events involved in D-V patterning in sequential order and name the main genes implicated Predict how loss of D-V patterning genes perturbs D-V axis patterning Explain how cell transplantation experiments can be used to identify the cells in which a particular gene product is required. Explain how a nuclear gradient of Dorsal is interpreted by target genes
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Dorso-ventral Patterning in Drosophila From ventral to dorsal: - Mesoderm - Neurectoderm - Lateral ectoderm - Dorsal ectoderm - Amnioserosa
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How are these different tissues specified ? Involves the establishment of a D-V gradient of Dorsal nuclear localization during the syncytial blastoderm stage - ventral nuclei: high levels of Dorsal - dorsal nuclei: low levels of Dorsal Dorsal starts out uniformly expressed in the cytoplasm throughout the embryo. Upon activation in ventral regions, it translocates to the nucleus of ventral and ventro-lateral cells only Dorsal is a transcription factor that specifies ventral cell fates
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How are dorsal fates initially specified ?
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