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To Register, visit: http://careers.umbc.edu/news_events/diversity.php.
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Biol 442, Second Half Anterior Posterior Dorsal Ventral Senesence Cancer Sex determination
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Th Oct 21 #14 RB Anterior-Posterior Pattern Formation in Drosophila I pp. 206-211, 218-239 Tu Oct 26 #15 RB Anterior-Posterior Pattern Formation in Drosophila II pp. 206-211, 218-239 Th Oct 28 #16 RB Dorsal-Ventral Pattern Formation in Drosophila pp. 211-217 Tu Nov 2 #17 RB Axis Formation in Vertebrates pp. 244-272, 298-300 Th Nov 4 #18 RB Limb Formation in Vertebrates Ch. 13 Tu Nov 9 #19 RB Organogenesis I: Central nervous system Ch. 9, 373-391 Th Nov 11 Exam 3 (Lectures 14-19) Tu Nov 16 #20 RB Organogenesis II: The digestive tube and its derivatives pp. 413-415, 471-478 Th Nov 18 #21 RB Cell Differentiation and Cancer Assigned Reading Tu Nov 23 #22 RB Senescence pp. 571-581 Th Nov 25 Thanksgiving Tu Nov 30 #23 RB Sex Determination Ch. 14 Th Dec 2 #24 RB Developmental Evolution Ch. 19 and Assigned Reading Tu Dec 7 #25 RB Ecological Developmental Biology Ch. 18 Th Dec 9 Exam 4 (Lectures 20-25) Th Dec 16 LH 2 Exam 5 (Lectures 1-25) 10:30 am -12:30am NOTE TIME Biol 442, Second Half
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Class organization Slides : Course content : knowledge on a particular topic Highlights : important principles, essential technical approaches Sidelights : topics of interest loosely related to topic of the day novelracers.blogspot.com Brainstorm : increase comprehension and understanding with in class exercises
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Biology 442 Developmental Biology Lecture 1 Anterior-Posterior Pattern Formation in the Drosophila Embryo I
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Learning objectives for this class Organize the different events involved in anterior-posterior patterning in sequential order and name the main genes implicated Relate the different mechanisms employed to pattern the embryo back to the developmental stage when they occur Explain forward genetics and how this approach has lead to gene discovery Predict how loss of maternal components or associated proteins may perturb anterior-posterior patterning Explain how maternal gradients are established in the early embryo Explain what a morphogen is and how it functions
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Nobel prize in physiology and medicine, 1995 Awarded for the discovery of "the genetic control of early embryonic development” in the fruitfly Drosophila. Genes identified have important functions during the early development of the human embryo. Example: formation of the body axis and the segmentation of the body. It is likely that mutations in such important genes are responsible for some of the early, spontaneous abortions that occur in man, and for some of the 40% of congenital malformations that develop due to unknown reasons
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Anterior-posterior patterning of the Drosophila embryo and adult
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Drosophila life cycle www.anatomy.unimelb.edu.au/.../ index.html
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I. Reminder: cleavage in insects
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