SCD and Malaria - Lecture 1 Hemoglobin and RBCs RBCs are...

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Lecture 1 Hemoglobin and RBC’s RBC’s are the most common cell (20-30 trillion). 25% of cells are RBC’s. Each red blood cell contains 300 mil copies of hemoglobin. 2.4 million RBC’s produced each second. -Hemoglobin- protein that transports O2 from lungs to tissues and transports carbon dioxide away. Hemoglobin is made of four protein chains/ polypeptide chains (Ribbon model) and these proteins, in turn, are composed of sequences of a.a. These sequences are linear in the manner of letters in a written sentence or beads on a string. The sequence of a.a.s determines the protein’s affinity for O2. Sickle Cell Disease/ Sickle Cell Anemia A heritable disease Recessive (both mother and father have a mutated form of the gene) This mutated gene (HbS) codes for an abnormal type of hemoglobin Two copies (one from each parent) of this gene cause RBCs to take on a ‘sickle shape’ in low oxygen conditions (HbS, HbS is the genotype) Symptoms: RBCs clump together and eventually block blood flow in small blood vessels- causes complications in every part of the body. Dizziness, headache, shortness of
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