Oct 1 - Biochem 423 Robert A. Orlando, Ph.D. REGULATION OF...

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Unformatted text preview: Biochem 423 Robert A. Orlando, Ph.D. REGULATION OF THE TCA CYCLE PYRUVATE DEHYDROGENASE P Pyruvate Dehydrogenase (INACTIVE) ADP NADH, acetyl CoA ADP, pyruvate Kinase subunit Ca2+ Phosphatase subunit ATP Pyruvate Dehydrogenase (ACTIVE) Pi NAD+, pyruvate NAD+ CoASH NADH CO2 NADH, acetyl CoA 87 | P a g e Biochem 423 Robert A. Orlando, Ph.D. ISOCITRATE DEHYDROGENASE ∆G = ‐ 5.3 88 | P a g e Biochem 423 Robert A. Orlando, Ph.D. ‐KETOGLUTARATE DEHYDROGENASE ∆G = ‐ 8.0 MALATE DEHYDROGENASE ∆G = + 7.1 REMEMBER: delta G = delta G0' + RT log([products]/[reactants]) WHERE delta G0' = ‐RT (ln Keq) 89 | P a g e Biochem 423 Robert A. Orlando, Ph.D. CLARIFICATION – NADH VERSUS FADH2 NAD+ → NADH + H+ FAD → FADH2 CH2 HO C H CH2 O CH2 C CH2 HCH HCH CH2 HC HC CH2 NAD+ = two electron transfers (oxidation of alcohol to ketone) FAD = one electron transfers (double bond formation) 90 | P a g e ...
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