Sept 20 - Biochem 423 Robert A. Orlando, Ph.D. SECTION 2:...

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Unformatted text preview: Biochem 423 Robert A. Orlando, Ph.D. SECTION 2: GENERATING ENERGY INTRODUCTION TO METABOLISM BODY ACTIVITIES = PHYSIOLOGICAL HOMEOSTASIS ENERGETICS X SYNTHESIS DISEASE ACTIVITY THERMOGENESIS PHYSICAL ACTIVITY RESTING METABOLIC RATE (BASAL METABOLIC RATE) ENERGY EXPENDITURE 10 % 20 % 70 % DEGRADATION (ENERGY NEEDS) (BUILDING BLOCKS) NOW….OF THE RESTING METABOLIC ACTIVITIES…. RESTING METABOLIC RATE (ENERGY EXPENDITURE) LIVER 27% BRAIN 19% HEART 7% KIDNEYS 10% SKELETAL MUSCLE 18% OTHER ORGANS 19% ORGAN 65 | P a g e Biochem 423 Robert A. Orlando, Ph.D. TOTAL ATP UTILIZATION ESTIMATED DAILY USE OF ATP HEART BRAIN KIDNEYS LIVER SKELETAL MUSCLE (REST) SKELETAL MUSCLE (RUNNING) (G ATP/G TISSUE) 16 6 24 6 0.3 23.6 HYDROLYSIS OF ATP FOR ENERGY UTP = carbohydrate synthesis GTP = protein synthesis CTP = lipid synthesis G = ‐ 7.3 kcal/mol 66 | P a g e Biochem 423 Robert A. Orlando, Ph.D. SOURCES OF ATP – START WITH MUSCLE (SELFISH ORGAN) THEN TO LIVER‐GLUCOSE STORAGE & ADIPOSE‐FAT STORAGE (ALTRUISTIC) O CH3‐C‐S‐COA Aerobic Anaerobic 67 | P a g e ...
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This note was uploaded on 12/11/2010 for the course BIOC 423 taught by Professor Robert during the Fall '10 term at New Mexico.

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