Sept 24 - Biochem 423 Robert A Orlando Ph.D GLYCOLYSIS –...

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Unformatted text preview: Biochem 423 Robert A. Orlando, Ph.D. GLYCOLYSIS – REACTIONS 2 PHASES OF GLYCOLYSIS NET EQUATION: GLUCOSE + 2 NAD + 2 PI + 2 ADP → 2 PYRUVATE + 2 NADH + 2 H+ + 2 ATP + 2 H2O + 73 | P a g e Biochem 423 Robert A. Orlando, Ph.D. GLYCOLYSIS – PREPARATIVE PHASE ∆G = ‐ 8.0 ∆G = ‐ 0.6 ∆G = ‐ 5.3 ∆G = + 0.6 ∆G = ‐ 0.3 74 | P a g e Biochem 423 Robert A. Orlando, Ph.D. GLYCOLYSIS – ATP GENERATING PHASE Coupled rxns to give ∆G = ‐ 0.4 OPO32‐ ∆G = ‐ 4.0 ∆G = ‐ 0.8 ∆G = + 0.2 75 | P a g e Biochem 423 Robert A. Orlando, Ph.D. WHAT IS NAD+ ? (NICOTINAMIDE ADENINE DINUCLEOTIDE) REMEMBER → LEO THE LION GOES GER LOSS OF ELECTRONS = OXIDATION GAIN OF ELECTRONS = REDUCTION 76 | P a g e Biochem 423 Robert A. Orlando, Ph.D. FOR EXAMPLE…. NAD+ → NADH + H+ FAD → FADH2 CH 2 HO C H CH2 O CH2 C CH2 HCH HCH CH2 HC HC CH2 NAD+ = two electron transfers (oxidation of alcohol to ketone) Oxidation states of carbon…. 77 | P a g e Biochem 423 Robert A. Orlando, Ph.D. ANAEROBIC GLYCOLYSIS – REGENERATION OF NAD+ IN O2 DEPRIVED MUSCLE 78 | P a g e Biochem 423 Robert A. Orlando, Ph.D. FRUCTOSE METABOLISM 79 | P a g e ...
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