Nov 3 - Biochem 423 Robert A. Orlando, Ph.D. CHOLESTEROL...

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Unformatted text preview: Biochem 423 Robert A. Orlando, Ph.D. CHOLESTEROL SYNTHESIS FUNDAMENTAL UNITS FOR CHOLESTEROL SYNTHESIS 156 | P a g e Biochem 423 Robert A. Orlando, Ph.D. ACETYL COA → MEVALONATE Looks like ketone body synthesis but happens in cytoplasm not mitochondria ENERGY EXPENSIVE Up to this point all steps are reversible 157 | P a g e Biochem 423 Robert A. Orlando, Ph.D. Rate-limiting committed step Target of statin therapy for cholesterol reduction Isoprene unit SEVERAL STEPS X3 158 | P a g e Biochem 423 Robert A. Orlando, Ph.D. 6 ISOPRENE UNITS CONDENSE TO FORM MANY STEPS CYCLASE ENZYMES 159 | P a g e Biochem 423 Robert A. Orlando, Ph.D. REGULATION OF CHOLESTEROL SYNTHESIS HMG‐COA REDUCTASE EXPRESSION SCAP = SREBP CLEAVAGE-ACTIVATING PROTEIN SREBP = STEROL REGULATORY ELEMENT-BINDING PROTEIN 160 | P a g e Biochem 423 Robert A. Orlando, Ph.D. REGULATION OF CHOLESTEROL UPTAKE FROM THE BLOOD 161 | P a g e ...
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This note was uploaded on 12/11/2010 for the course BIOC 423 taught by Professor Robert during the Fall '10 term at New Mexico.

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