Oct 25 - Biochem 423 Robert A Orlando Ph.D SECTION 5 LIPID...

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Unformatted text preview: Biochem 423 Robert A. Orlando, Ph.D. SECTION 5: LIPID METABOLISM FATTY ACID SYNTHESIS NOMENCLATURE – WHAT IS A FATTY ACID? 1 2 3 16:0 = PALMITATE 18:0 = STEARATE 16:1(9) = PALMITOLEATE 18:1(9) = OLEATE 18:2(9,12) = LINOLEATE 18:3(9,12,15) = LINOLENATE Fatty acyl‐CoA desaturase Essential fatty acids from plants 130 | P a g e Biochem 423 Robert A. Orlando, Ph.D. WHY DO WE SYNTHESIZE FATTY ACIDS? – LIVER AND ADIPOSE OR Dietary sources lipoprotein 131 | P a g e Biochem 423 Robert A. Orlando, Ph.D. GLUCOSE → FATTY ACIDS to FA synthesis * Citrate—Malate anti‐transporter 132 | P a g e Biochem 423 Robert A. Orlando, Ph.D. SOURCE OF CITRATE FOR FATTY ACID SYNTHESIS – TCA CYCLE to FA synthesis ACONITASE + 1.5 KCAL ISOCITRATE DEHYDROGENASE ‐ 5.3 KCAL + ADP NADH, ATP 133 | P a g e Biochem 423 Robert A. Orlando, Ph.D. 1ST STEP IN FATTY ACID SYNTHESIS ACETYL COA → MALONYL COA CONVERSION Building block for FA synthesis 134 | P a g e Robert A. Orlando, Ph.D. 2) reduction P = Acyl carrier protein 1) condensation FATTY ACID SYNTHASE COMPLEX ← REPEAT 3) dehydration Biochem 423 4) reduction 135 | P a g e Biochem 423 Robert A. Orlando, Ph.D. 136 | P a g e Biochem 423 Robert A. Orlando, Ph.D. REGULATION OF ACETYL COA CARBOXYLASE Insulin Liver and Adipose Tissue Glucagon 137 | P a g e Biochem 423 Robert A. Orlando, Ph.D. MALONYL COA REGULATION OF CPT I carnitine:palmitoyl transferase I and II CARNITINE—FATTY ACID COMPLEX FOR TRANSPORT 138 | P a g e Biochem 423 Robert A. Orlando, Ph.D. SUMMARY OF FATTY ACID SYNTHESIS & ASSEMBLY IN LIVER 139 | P a g e ...
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