Oct 27 - Biochem 423 Robert A Orlando Ph.D STARVATION –...

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Unformatted text preview: Biochem 423 Robert A. Orlando, Ph.D. STARVATION – KETONE BODY METABOLISM KETONE BODIES APPEAR DURING PROLONGED FAST 140 | P a g e Biochem 423 Robert A. Orlando, Ph.D. OVERVIEW OF KETONE BODY METABOLISM Muscle and Brain 141 | P a g e Biochem 423 Robert A. Orlando, Ph.D. STRUCTURES OF MAJOR KETONE BODIES O CH3 C CH3 Acetone O O CH3 C CH2 C O- Acetoacetate OH CH3 C H CH2 O C O- -hydroxybutyrate 142 | P a g e Biochem 423 Robert A. Orlando, Ph.D. KETONE BODY SYNTHESIS Reversal of last step of -oxidation 143 | P a g e Biochem 423 Robert A. Orlando, Ph.D. KETONE BODY USED AS FUEL The last step of -oxidation 144 | P a g e...
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