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Unformatted text preview: Biochem 423 Robert A. Orlando, Ph.D. ETHANOL METABOLISM OBJECTIVES: 1. MAKE BEER (BREAD AND BIO‐FUELS) 2. DRINK BEER 3. METABOLIZE BEER ANAEROBIC RESPIRATION IN HUMANS – A REVIEW 145 | P a g e Biochem 423 Robert A. Orlando, Ph.D. ANAEROBIC RESPIRATION IN YEAST ANCIENT ART OF BEER MAKING Cereal grains (seeds of barley, wheat) malting process (germination) Glycolytic enzymes released (cellulase, amylase, etc) mix with wort (nutrient medium) heat with hops for flavor cool and aerate (for initial boost of O2) Digested polysaccharides (glucose, fructose) add yeast (initial replication with O2) Fermentation when O2 i2) depleted (ethanol + CO s 146 | P a g e Biochem 423 Robert A. Orlando, Ph.D. ANCIENT ART OF DRINKING BEER METABOLIZING BEER NAD+ NADH NAD+ NADH Alcohol Dehydrogenase Acetaldehyde Dehydrogenase Liver & Muscle (Blood) CoASH ATP Toxic (liver damage) and…. induces nausea, vomiting AMP + PPi TCA cycle and more NADH Acetyl CoA Synthetase 147 | P a g e Biochem 423 Robert A. Orlando, Ph.D. CONSEQUENCES OF TOO MUCH ALCOHOL FOR THE LIVER BLOOD PH < 6.7 = INCOMPATIBLE WITH LIFE 148 | P a g e ...
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This note was uploaded on 12/11/2010 for the course BIOC 423 taught by Professor Robert during the Fall '10 term at New Mexico.
- Fall '10