cell biology review

cell biology review - BIOL2030 CellBiology FINALREVIEW

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11 BIOL 2030 Cell  Biology FINAL REVIEW     Cell Communication (Ch 16) Cell Cycle (Ch 18)
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22 Cell  Communication EXTRACELLULAR FLUID Receptor Signal molecule Relay Molecules Plasma membrane CYTOPLASM Activation of cellular response Reception 1 Transduction 2 Response 3
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Signals Can Act over a Long or Short Range
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Figure 16-8 Essential Cell Biology (© Garland Science 2010) Signal molecules can act on proteins receptors in  different cellular locations
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Cell-Surface Receptors Fall into Three Main Classes
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G-Protein Coupled Receptors  Large family of receptors all with similar structure 7 transmembrane loops Couple with G-proteins ~800 different GPCRs in humans that perform a plethora of  different functions Vision e.g. rhodopsin Smell e.g. olfactory receptors Neurotransmission e.g. serotonin + dopamine receptors 66
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Cell-Surface Receptors Relay Extracellular Signals via  Intracellular Signaling Pathways
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GPCR activation typically causes one of  cAMP IP3 Ion channel s 88 Slow or fast cell response Slow or fast cell response Fast cell response
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You are strolling through the woods and  you suddenly see a bear Activation of sympathetic (fight or flight) nervous system Release of 'fight or flight' hormone epinephrine (adrenaline) It acts on a GPCR ( 2-adrenergic receptor -  2AR) that sets  β β off the SAME intracellular signalling cascade in many different  cell types / tissues But the end cell response is different in different cells/tissues Hence epinephrine mediates multiple effects via the same  receptor
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This note was uploaded on 12/11/2010 for the course BIO 2010 taught by Professor Kirk during the Spring '10 term at UOIT.

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cell biology review - BIOL2030 CellBiology FINALREVIEW

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