Stem Cells Main Presentation-1

Stem Cells Main Presentation-1 - StemCells GROUPMEMBERS...

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GROUP MEMBERS:   KALPI DESAI JAMIE JAMES SCOTT HOLMES KRISHNA MASOOR Stem Cells 
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Background Definition: Undifferentiated cells Develop into specialized cells Four types: Pluripotent Multipotent Induced Totipotent
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Pluripotent (Embryonic)  Derived from blastocyst Can differentiate into  most cells in body
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Multipotent (Adult) Adult stem cell (SC) Give rise to some types of cells More limited than pluripotent SC Induced pluripotent SC Adult SC with pluripotent characteristics
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Totipotent Derived from zygote Can differentiate into  any type of cell Can form new organism
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Stem Cells: When and Where
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Hierarchy of Stem Cells Multipotent Totipotent Pluripotent
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What defines “Stemness”? Ability to multiply Stem cells (SC) retain ability to grow for weeks to years Gene expression or immunological assays* Analysis of all DNA/RNA transcripts in cell  Surface markers via antibodies Unspecialized and differentiable *Bottom Line: Although tissue-specific markers exist, little is known about  proteins or transcripts that characterize  all  stem cells
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This note was uploaded on 12/13/2010 for the course CHEM 3510 taught by Professor Kemp during the Spring '10 term at Georgia Tech.

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Stem Cells Main Presentation-1 - StemCells GROUPMEMBERS...

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