TENTATIVE LECTURE SCHEDULE
Membrane potential 57-61
The unit introduces many fundamental concepts of physiological processes and will use these concepts
construct the explanation of the monosynaptic reflex.
The ideas used in this explanation are: changes
in ionic conductance, local current, the all-or-none nature of the action potential, membrane receptors
and their interaction with second messengers, graded potentials, summation, filtering, integration, sum
of positive and negative input, coding and contractile cell function.
By the end of this section you
should be able to:
Compare and contrast the mechanisms involved in the movement of substances across a membrane.
Discuss the role of the proposed structure of the cell membrane in these processes.
osmosis, the variety of protein mediated transport and vesicle mediated transport.
Compare and contrast an equilibrium potential (E
) and a steady state membrane potential (V
Discuss the implications of the following: Nernst equation, the Goldman equation and I
Use these equations to identify the effect of changes in ionic concentration gradients and ionic
permeability’s on Vm.
Diagram and explain the proposed ion and charge movements during an action potential in a
motorneuron and in skeletal muscle.
Include the present thinking on channels in your discussion.
Describe the theory for action potential propagation in mylenated and unmylenated neurons.
Compare and contrast the functional characteristics of a synapse between neurons and a neuromuscular
Compare and contrast the characteristics and function of proposed transmitters.
and contrast an EPSP and IPSP.
Discuss the formation and the function of second messengers such as cAMP, cGMP, IP
, DAG and
calcium ions in the cell.