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1 HK*3940 HUMAN PHYSIOLOGY FALL 2010 TENTATIVE LECTURE SCHEDULE Communication Date – 2010 Section Lecture 11 th edition readings (pages) 12 th edition readings (pages) Sep-09 Thursday 1. Communication: Principles Introduction Transport 19-20,45-56 18-19,45-56 Sep-10 Friday Membrane potential 57-61 57-60 Sep-13 Monday Action Potential 61-70 60-69 Sep-14 Tuesday Synapse 85-89, 559-564 83-86, 546-557 Sep-15 Wednesday Synapse Sep-16 Thursday Regulation 910-915 887-891 Sep-17 Friday Contractile cells 72-78, 89-91 71-89 Sep-20 Monday Contractile cells 80-83, 92-99, 572-576 91-104, 560-563 Sep-21 Tuesday Monosynaptic reflex The unit introduces many fundamental concepts of physiological processes and will use these concepts construct the explanation of the monosynaptic reflex. The ideas used in this explanation are: changes in ionic conductance, local current, the all-or-none nature of the action potential, membrane receptors and their interaction with second messengers, graded potentials, summation, filtering, integration, sum of positive and negative input, coding and contractile cell function. By the end of this section you should be able to: Compare and contrast the mechanisms involved in the movement of substances across a membrane. Discuss the role of the proposed structure of the cell membrane in these processes. Consider diffusion, osmosis, the variety of protein mediated transport and vesicle mediated transport. Compare and contrast an equilibrium potential (E ion ) and a steady state membrane potential (V m ). Discuss the implications of the following: Nernst equation, the Goldman equation and I ion =g ion (V m - E ion ). Use these equations to identify the effect of changes in ionic concentration gradients and ionic permeability’s on Vm. Diagram and explain the proposed ion and charge movements during an action potential in a motorneuron and in skeletal muscle. Include the present thinking on channels in your discussion. Describe the theory for action potential propagation in mylenated and unmylenated neurons. Compare and contrast the functional characteristics of a synapse between neurons and a neuromuscular junction. Compare and contrast the characteristics and function of proposed transmitters. Compare and contrast an EPSP and IPSP. Discuss the formation and the function of second messengers such as cAMP, cGMP, IP 3 , DAG and calcium ions in the cell.
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2 Compare and contrast skeletal muscle and smooth muscle function under the following headings: structure and protein content, mechanism of contraction, excitation-contraction coupling and processes involved in relaxation. Outline the proposed mechanisms and characteristics of a generator (receptor) potential. Discuss the role of summation in synaptic and skeletal muscle function. List and discuss the mechanisms available or involved in coding sensory information in a monosynaptic reflex arc.
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