Lab 7 mitosis-meiosis-medelian_genetics

Lab 7 mitosis-meiosis-medelian_genetics - Anouncements...

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Unformatted text preview: Anouncements Anouncements If you need supplies for your experiment make If sure to see me today during or after class to remind me remind Average on test was 22 Meiosis and Mendelian Genetics Genetics Lab 7 Scenario-discussion Scenario-discussion Down Syndrome Inheritance of a third chromosome (#21) when Inheritance gamete was formed gamete Chances increase with age of mother Chances Due to abnormal egg production Due Or the older female body not having the mechanism to Or recognize an abnormal fetus and automatically abort the baby baby Can be diagnosed through Karyotyping Karyotype Karyotype A method of organizing the chromosomes method of a cell in relation to their number, size, and type. and Can be used to diagnose diseases related Can to the number of chromosomes a person has (ex. Down Syndrome, Klinefelters syndrome) syndrome) Typically, each cell of Typically, your body has 46 chromosomes..23 from each parent each So, you have what we call So, a Diploid value of 46, or Diploid referred to as 2N 2N Karyotype -Phototograph of chromosome set Down Syndrome Karyotype Down Syndrome Karyotype • Trisomy on chromosome 21 • Notice there are three • Amazing how such a small defect can cause such pronounced physical defects Mitosis vs Meiosis Mitosis Mitosis Meiosis Produces body cells Produces (Somatic cells) (Somatic Daughter cells are Daughter diploid diploid 1 cell division There are TWO There daughter cells daughter Produces sex cell Produces (Gametes) (Gametes) Daughter cells are Daughter haploid haploid 2 cell divisions There are FOUR There daughter cells daughter Mitosis Mitosis each division gives 2 identical products 1 diploid Cell 2 diploid Cells http://tidepool.st.usm.edu/pix/mitosis.jpg Genetics Vocab Genetics Allele – particular type of single gene (blue eyes and brown eyes are different alleles, or a+ and a) Homozygous – when chromosomes from each parent has the same allele (a+/a+ or a/a) Heterozygous – when chromosomes from each parent have different alleles (a+/a or a/a+) Genotype – the combination of different alleles that make up an individual (a+/a, b/b+, etc.) maternal paternal (**See appendix C for more definitions**) Homologous chromosomes Genetics Vocab Genetics Dominant allele – trait that will be expressed over a recessive one. Designated with a capitol letter (B) Recessive allele – trait that will be covered up by a dominant one. Designated with a small letter (b) Phenotype – expressed trait that results from the combination of alleles Genotype B/B B/b b/b Phenotype Black hair Black hair Brown hair Homologous chromosomes Let B be the allele for black hair Let b be the allele for brown hair Hair color gene B b Meiosis Meiosis Cell division process in which the number of chromosomes is Cell cut in half. cut Results in the formation of gametes …eggs and sperm Results Allows for sexual reproduction in eukaryotes Allows eukaryotes Meiosis is basically mitosis occurring twice But the DNA is only replicated once (interphase) Meiosis allows for shuffling of genes with Crossing over Meiosis Meiosis Once gametes are formed: They combine with a gamete of another individual and They undergo fertilization fertilization Producing a zygote (2n) Producing zygote Genotype formation in new individual (1/2 from mom, 1/2 Genotype from dad) from Phenotype expression dependent upon the alleles (different Phenotype versions of same gene) inherited, whether they are dominant or recessive, and whether the offspring is homozygous or heterozygous homozygous Meiosis allows for Meiosis I & II Meiosis •Prophase I: chrom. Condense, homolougous chrom. pair up •Metaphse I: Homologues line up at equator •Anaphase I: Homologues are separated into 2 groups (some mom, some dad) •Telophase I: new nuclei form •Prophase II: Chrom. Condense •Metaphase II: Chrom. Line up at the equator •Anaphase II: Chromatides are separated •Telophase II: Each daughter cell from Meiosis I will form 2 more cell for a total of 4 cells (4 sperm, 1 viable egg) Meiosis 1 Meiosis http://www.dac.neu.edu/biology/c.ellis/genmolbio/index.htm Meiosis 1 Meiosis http://www.dac.neu.edu/biology/c.ellis/genmolbio/index.htm Meiosis 1 Meiosis http://www.dac.neu.edu/biology/c.ellis/genmolbio/index.htm Meiosis 1 Meiosis http://www.dac.neu.edu/biology/c.ellis/genmolbio/index.htm Meiosis 2 Meiosis http://www.dac.neu.edu/biology/c.ellis/genmolbio/index.htm Meiosis 2 Meiosis http://www.dac.neu.edu/biology/c.ellis/genmolbio/index.htm Meiosis 2 Meiosis http://www.dac.neu.edu/biology/c.ellis/genmolbio/index.htm Meiosis 2 Meiosis http://www.dac.neu.edu/biology/c.ellis/genmolbio/index.htm Mendelian Genetics Mendelian Mendel's First Law - segregation of alternate factors Alternative versions of genes (called alleles) account for variations in inherited characteristics For each character, an organism inherits two alleles, one from each parent If the two alleles differ, then one, the DOMINANT, is fully expressed in the organisms appearance (phenotype); the other, the RECESSIVE, has no noticeable effect on the organisms appearance The two alleles for each character segregate during gamete production Punnet Square Punnet Genotype: ¼=RR ¼=rr ½=Rr Phenotype: 3/4=RR ¼=rr RR Rr Rr rr Investigation 1 Modeling Meiosis Modeling Demonstration of meiosis on the white board - the Demonstration “dance of the chromosomes” “dance As a class, use the models to answer questions Dysjunction - failure of chromosomes to separate Dysjunction Investigation 1 Modeling Meiosis Modeling How is meiosis different from mitosis? Meiosis is 2 divisions resulting in 4 haploid cells Mitosis is 1 division resulting in 2 diploid cells Each has its own purpose Both are mechanisms for cell division Meiosis II is similar to mitosis - sister chromatids separate How are they similar? Investigation 2 Animal and Plant Mitosis On page 120, step 2 says to draw stages of mitosis in Figure 7­9, should be Figure 7­4. On page 119, the website address is wrong. The correct one is http://biog­1101­ 1104.bio.cornell.edu/BioG101_104/tutorials/cell_division.html Identify stages of mitosis in plant and animal cells Working in groups of 2 or 3 and following the website for help Look at different slides from different groups and try to find the different stages Investigation 3 Investigation Modeling Meiosis Parents have 2 of each chromosome Parents Every gamete gets 1 of each chromosome Fertilization is a random combination of these Fertilization gametes gametes Investigation 3 Investigation Independent Segregation Most alleles come in pairs - one dominant and Most one recessive recessive Dominant - only one copy needed for characteristics Dominant (Brown eyes - B) Recessive – trait is only seen if NO dominant allele Recessive is present (Blue eyes - b) Use punnett squares to predict phenotypes Example: Coat color in sheep Investigation 4 Punnett Squares Investigation On page 123, should be titled Investigation 4 On Groups of two or three with the computer. Review two websites on constructing Punnett Review squares. First website is a tutorial 2nd website is what you base your responses on (Test Crosses section, do not go beyond this) (Test Look to the course website to find these websites Look ...
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