Lecture+10_Siobhan

Lecture+10_Siobhan - Introduction to clickers You should...

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Introduction to clickers You should know how to: - navigate clicker menus - enter your student ID # - join a class - answer a question Helpful hints: - “I Use A Clicker” pdf file on course website - clicker goes to sleep to save power. Any button will wake it up, but don’t turn it off or you will have to rejoin the class - you can’t share a clicker with a friend
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Clickers in BIS101 - There will be clicker questions in every lecture. They will contribute to your grade starting from this lecture. - Points: 1 point for any answer, 0 points for no answer. - Points will be averaged to make the equivalent of a pop quiz. - I will always use multiple-choice, with letters
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Does my clicker work? A. Yes A. No
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BIS101 Lecture 10 10/28/10 DNA Structure  Replication Sequence Analysis pp. (7)265-291, (20)731-735
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• Siobhan Brady • Office Hours: Tuesday and Thursday 10:15- 11:15 am • 2251 LSA • Email: sbrady@ucdavis.edu
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• Responsible for all material within assigned  reading
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Forget going into a classroom and saying, ‘I am going to  teach you about Watson and Crick and the double helix,’ ”  Professor Gates said. “Imagine if I could say, ‘With this  cotton swab, we can tell you where your ancestors come  from in Africa.’ ” Dr Henry Louis Gates Jr. Professor of African-American Studies, Harvard U. creator of PBS show “African American Lives”
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LECTURE 10: OUTLINE DNA structure: a double helix made of antiparallel  nucleotide polymers DNA replication: Semi-conservative replication DNA polymerases Replication is bidirectional and initiates at specific  sites Replication requires multiple enzymatic reactions Chromosome ends require special replication Biotechnology Applications: PCR DNA sequencing
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James Watson and Francis Crick, 1953 
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Rosalind Franklin
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The Structure of DNA Requisite properties of the genetic material: 1. Can be replicated faithfully 2. Possesses sufficient informational content 3. Must be able to mutate (but rarely!)
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What is the structure of DNA? • Model building  • Assemble puzzle pieces into a predictive model • Determine if the model fits the observed data • 3 pieces of data
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1. Structure of nucleotides 1. Chargaff’s composition 1. X-ray diffraction pattern
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Base Nucleoside Nucleotides (base + sugar) (base + sugar + phosphate) DNA Adenine (A) Deoxyadenosine dAMP, dADP, dATP Guanine (G) Deoxyguanosine
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This note was uploaded on 12/17/2010 for the course BIS 101 taught by Professor Simonchan during the Fall '08 term at UC Davis.

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Lecture+10_Siobhan - Introduction to clickers You should...

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