F10_L06_NT_systems

F10_L06_NT_systems - Psy 111 Basic concepts in...

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Unformatted text preview: Psy 111 Basic concepts in Biopsychology Lecture 6: Neurotransmitter Systems Objectives Identify the criteria for molecules to serve as a neurotransmitter; discuss types of molecules that fulfill these criteria and techniques to study them. Describe the variability in synaptic morphology and function. Survey the major classes of neurotransmitters: amino acids, amines, peptides. Provide a framework for consideration of levels of neurotransmission Discuss glutamate as the major excitatory NT Discuss GABA as the major inhibitory NT Discuss the amines and general function Describe neuropeptides Discuss retrograde transmission. Compartmentalization Dendrites = input Body = protein production Initial Segment = integration Axon = conduction Terminal = output Input into a neuron is based on chemical transmission which is turned into an electrical signal or activation of intracellular signaling pathways which determines output. Neurotransmitter Systems: Criteria for neurotransmitters: 1. Synthesized and stored in presynatpic neuron 2. Released from presynatpic neuron on stimulation (i.e. as result of AP) 3. Exogenous application mimics endogenous action Types of Neurotransmitters Amino Acids Amines Peptides Focus on:-synthesis & storage-receptors/effectors-level of control-pharmacology Peptides and Amino Acid Derived NTs. Peptides synthesized on rER & transported via microtubules Amines/amino acids synthesized and packaged for later release Studying NT Systems In situ hybridization to detect mRNA; localize RNA to cell body. Studying NT Systems Immunocytochemistry to detect specific proteins; can be peptide neurotransmitter, synthetic proteins, or vesicular transporters. Radio-labeling of neurotransmitter or ligand which binds to specific receptors . Studying NT Systems Microdialysis Uses a probe with a thin membrane that is permeable to neurotransmitters (i.e. they can cross membrane). Probe is lowered into a brain region, neurotransmitters cross membrane and are collected and analyzed using various chemical techniques....
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This note was uploaded on 12/18/2010 for the course PSYCH 111 taught by Professor Kippen during the Fall '08 term at UCSB.

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F10_L06_NT_systems - Psy 111 Basic concepts in...

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