F10_L10_spinal_motor

F10_L10_spinal_motor - Psy 111 Basic concepts in...

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Psy 111 Basic concepts in Biopsychology Lecture 10: Spinal Control of Muscle
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Primary cortices
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Objectives Describe the anatomy, structure, and activation of skeletal muscle. Describe the neuromuscular junction and its control of skeletal muscle. Define motor units, pools, and muscle groups. Describe the basic reflexes: myotatic, reverse myotactic, reciprocal inhibition, and the flexsor reflexes. Explain the relation between basic reflexes and walking at the spinal level.
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Motor Systems 1. Structure and activation of muscle 2. Neuronal innervation of muscle 3. Spinal reflexes 4. Descending motor pathways (next day) 5. Brain control of motor system (next day)
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Appearance and Innervation of Muscle Muscle is made up of fibers that appear striated and the fibers are sparsely innervated by axons from the spinal cord in a non- overlapping fashion. Motor neuron excitation produces muscle contraction = basis of all movement.
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Anatomy of a Muscle fiber •Myofibril bundles comprise a muscle fiber. •Fiber is encased in sarcoplasmic reticulum. •T-Tubules connect the sacroplasmic reticulum to sarcolemma. •Sarcolemma is an excitable membrane (nAChRs) surrounding muscle fibers. Activation: Sarcolemma -> t-tubule -> sarcoplasmic reticulum -> myofibrils.
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Structure of myofibril •Myofibril comprises of two types of filaments: thick and thin. •The basic unit of a myofibril is the “sacromere” which is comprised of the overlapping thin and thick filaments between a Z-line. •Thin filaments are attached to Z-line. •Thick filaments held in place between the thin filaments.
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Thin Filaments: contain actin, tropomyosin, and troponin (regulator proteins). Thick Filament : contain myosin; ATP binding enzyme. Functional Components of a Sacromere
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Thick Filaments Thick filament is comprised of multiple myosin proteins which can: (1) bind ATP; (2) crosslink to thin filaments. (3) move/bend (generate force);
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Thin Filaments Thin filaments contain 3 proteins: (1) G actin which binds myosin (2) Tropomyosin which can block myosin-actin binding (3) Troponin which binds Ca++ to remove tropomyosin block of myosin-actin binding.
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Contraction of Myofibril Sacromere shortens and generates force through the movement of thick and thin
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F10_L10_spinal_motor - Psy 111 Basic concepts in...

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