Lecture2110f

Lecture2110f - Chemistry 83Chemistry 83 11/18/1011/18/10 1...

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Unformatted text preview: Chemistry 83Chemistry 83 11/18/1011/18/10 1 Technologies Associated with Pharmaceuticals (Drugs) Drug is a substance, other than food or water, that affects how a body functions. Drugs having a positive effect are called medicines. Origins of Drugs Suchocki,J.,Conceptual Chemistry, 3rd, Pearson,Boston,2007,480 Chemistry 83Chemistry 83 11/18/1011/18/10 2 Example: drug known since 400 BC Hippocrates, Father of Medicine, used an extract, prepared by boiling bark from a willow tree in water, to reduce fevers and pain This folk remedy was used for centuries, but was not scientically studied until 1827 when an active component, salicin, was isolated Snyder, Extraordinary Chemistry, Wiley, NY, 1992, 604 Medicinal chemistry is concerned with the discovery, identication, synthesis, development of new drugs and optimization of existing drugs Snyder, Extraordinary Chemistry, Wiley, NY, 1992, 605 Salicin from willow bark reacts with water to produce glucose and salicyl alcohol. In humans, salicyl alcohol is oxidized to salicylic acid which is the active substance that reduces fever (anti- pyretic), pain (analgesic), and inflammation (anti-inflammatory agent). Chemistry 83Chemistry 83 11/18/1011/18/10 2 Example: drug known since 400 BC Hippocrates, Father of Medicine, used an extract, prepared by boiling bark from a willow tree in water, to reduce fevers and pain This folk remedy was used for centuries, but was not scientically studied until 1827 when an active component, salicin, was isolated Snyder, Extraordinary Chemistry, Wiley, NY, 1992, 604 Medicinal chemistry is concerned with the discovery, identication, synthesis, development of new drugs and optimization of existing drugs Snyder, Extraordinary Chemistry, Wiley, NY, 1992, 605 Salicin from willow bark reacts with water to produce glucose and salicyl alcohol. In humans, salicyl alcohol is oxidized to salicylic acid which is the active substance that reduces fever (anti- pyretic), pain (analgesic), and inflammation (anti-inflammatory agent). Chemistry 83Chemistry 83 11/18/1011/18/10 3 Snyder, Extraordinary Chemistry, Wiley, NY, 1992, 606 80 B tablets/yr sold in US Although salicylic acid reduces pain, fever, and inflammation, it is far too corrosive to tissues in the stomach to be taken internally by most people. In 1893 Felix Hofman, a chemist working for the Bayer firm in Germany, converted salicyclic acid to acetylsalicylic acid which can be better tolerated by most people....
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This note was uploaded on 12/19/2010 for the course CHEM 83 taught by Professor Bonk,j during the Fall '08 term at Duke.

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Lecture2110f - Chemistry 83Chemistry 83 11/18/1011/18/10 1...

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