Lecture3 - BCH 227 FALL 2010 LECTURE 3 WATER ACID-BASE...

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1 Water Acid-Base Chemistry BIOCHEM 227 FALL 2010 Lecture 3 Friday, September 3, 2010 TODAY • Continue: thermo • Properties of water, and interactions of molecules in aqueous solvent • Acid/base chemistry BCH 227 FALL 2010 LECTURE 3: WATER, ACID-BASE CHEMISTRY 3 SEP 2010
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2 3- 4 5 ATP ADP PO 30 kJ/mol 21 0 eq G K + Δ° ≈× R BCH 227 FALL 2010 LECTURE 3: WATER, ACID-BASE CHEMISTRY 3 SEP 2010
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3 ln GG R T Q Δ= Δ° + ln R T Q Δ =Δ °+ (l n ) ln R T Q d Q GQ RTQ RTQ Q C ° + =Δ° − + + BCH 227 FALL 2010 LECTURE 3: WATER, ACID-BASE CHEMISTRY 3 SEP 2010
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4 Free Energy ln eq GR T K Δ° = Thermo vs. Kinetics Just because it is energetically favorable doesn’t mean it will actually happen! BCH 227 FALL 2010 LECTURE 3: WATER, ACID-BASE CHEMISTRY 3 SEP 2010
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5 Activation Energy & Catalysis Activation Energy & Catalysis BCH 227 FALL 2010 LECTURE 3: WATER, ACID-BASE CHEMISTRY 3 SEP 2010
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6 Arrhenius Equation a E RT kA e = where, from transition-state theory: A = k b T / h E a = Δ G Coupling of Processes BCH 227 FALL 2010 LECTURE 3: WATER, ACID-BASE CHEMISTRY 3 SEP 2010
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7 Water Water BCH 227 FALL 2010 LECTURE 3: WATER, ACID-BASE CHEMISTRY 3 SEP 2010
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8 Water Strong electric dipole Dielectric constant = 78.5 (cf. benzene = ~5) Hydrogen Bond Energy: 5.5 kcal/mol 10% covalent 90% electrostatic (cf. Covalent Bond Energy: 112 kcal/mol) Hydrogen Bonding BCH 227 FALL 2010 LECTURE 3: WATER, ACID-BASE CHEMISTRY 3 SEP 2010
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9 Hydrogen Bonding Hydrogen Bonding BCH 227 FALL 2010 LECTURE 3: WATER, ACID-BASE CHEMISTRY 3 SEP 2010
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10 Hydrogen Bonding Generally speaking, occurs… – when a very electronegative atom is bonded to H (the donor ) – when this group is close in space to another electronegative atom (the acceptor ) – when the donor and acceptor are arranged in a straight line • The more electronegative the donor and/or acceptor, the stronger the H-bond BCH 227 FALL 2010 LECTURE 3: WATER, ACID-BASE CHEMISTRY 3 SEP 2010
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11 Ice Hydrophobic/Hydrophilic BCH 227 FALL 2010 LECTURE 3: WATER, ACID-BASE CHEMISTRY 3 SEP 2010
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12 Solvation of Hydrophilics
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This note was uploaded on 12/19/2010 for the course BIOCHEM 227 taught by Professor Coggins during the Fall '10 term at Duke.

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Lecture3 - BCH 227 FALL 2010 LECTURE 3 WATER ACID-BASE...

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