Lecture7 - BCH 227 FALL 2010 LECTURE 7: PROTEIN FOLDING,...

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1 Protein Folding, Dynamics and Evolution BIOCHEM 227 FALL 2010 Lecture 7 Monday, September 13, 2010 TODAY • Continued: protein quarternary structure • Continued: membrane protein structure • Protein folding •P ro t e in dyn
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2 Protein Quaternary Structure Quaternary Structure • Technically refers to multiple chains • In practice, similar principles any time two domains interact BCH 227 FALL 2010 LECTURE 7: PROTEIN FOLDING, DYNAMICS AND EVOLUTION 13 SEP 2010
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3 Dimers • Two independent chains that bind noncovalently – Often two copies of the same chain (homodimer) – Sometimes two different chains (heterodimer) – Symmetry is common Multimers BCH 227 FALL 2010 LECTURE 7: PROTEIN FOLDING, DYNAMICS AND EVOLUTION 13 SEP 2010
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4 Multimers • Example: hemoglobin – Two alpha and two beta subunits – Symmetric – Four heme groups GroEL/GroES BCH 227 FALL 2010 LECTURE 7: PROTEIN FOLDING, DYNAMICS AND EVOLUTION 13 SEP 2010
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5 Protein Assemblies Protein Assemblies BCH 227 FALL 2010 LECTURE 7: PROTEIN FOLDING, DYNAMICS AND EVOLUTION 13 SEP 2010
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6 Protein Assemblies Protein Assemblies BCH 227 FALL 2010 LECTURE 7: PROTEIN FOLDING, DYNAMICS AND EVOLUTION 13 SEP 2010
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7 Virus Capsids Tomato Bushy Stunt Virus Virus Capsids (a) Tomato bushy stunt virus
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Lecture7 - BCH 227 FALL 2010 LECTURE 7: PROTEIN FOLDING,...

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