Lecture8 - BCH 227 FALL 2010 LECTURE 8: INTRO TO ENZYMES 15...

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1 Intro to Enzymes BIOCHEM 227 FALL 2010 Lecture 8 Wednesday, September 15, 2010 TODAY • Continued: evolution of protein structure •In t ro to En zym e s BCH 227 FALL 2010 LECTURE 8: INTRO TO ENZYMES 15 SEP 2010
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2 Evolution of Protein Structure Structures and Evolution Why do so many proteins have similar structures? BCH 227 FALL 2010 LECTURE 8: INTRO TO ENZYMES 15 SEP 2010
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3 Structures and Evolution • Example: DNA-binding homeodomain –yeast vs . Drosophila Structures and Evolution •Ex amp l e : S e r in e p ro t e a s e s – green residues are the same BCH 227 FALL 2010 LECTURE 8: INTRO TO ENZYMES 15 SEP 2010
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4 Thioredoxin Domain • Thioredoxins, peroxiredoxins, CMPs Evolution of Thioredoxin Family Copley et al. Biochemistry 43 : 13981-13995 (2004). BCH 227 FALL 2010 LECTURE 8: INTRO TO ENZYMES 15 SEP 2010
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5 Quaternary Structure Copley et al. Biochemistry 43 : 13981-13995 (2004). Active Sites Copley et al. Biochemistry 43 : 13981-13995 (2004). BCH 227 FALL 2010 LECTURE 8: INTRO TO ENZYMES 15 SEP 2010
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6 Copley et al. Biochemistry 43 : 13981-13995 (2004).
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This note was uploaded on 12/19/2010 for the course BIOCHEM 227 taught by Professor Coggins during the Fall '10 term at Duke.

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Lecture8 - BCH 227 FALL 2010 LECTURE 8: INTRO TO ENZYMES 15...

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