Lecture12 - BCH 227 FALL 2010 LECTURE 12: STRUCTURE &...

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1 Structure and Function in Enzymes BIOCHEM 227 FALL 2010 Lecture 12 Friday, September 24, 2010 TODAY • A few more words on inhibition • Continued: structure and function in enzymes –Eno lase –LpxC –A ldo lase BCH 227 FALL 2010
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2 Reversible Inhibition Competitive inhibition – inhibitor competes with substrate for access to the active site –a lters K M Reversible Inhibition Uncompetitive inhibition – inhibitor binds to ES complex –a lters V max and K M BCH 227 FALL 2010 LECTURE 12:
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3 Reversible Inhibition Mixed inhibition – inhibitor binds to E or ES – also alters both V max and K M Structure and Function in Enzymes BCH 227 FALL 2010 LECTURE 12: 24 SEP 2010
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4 Enolase • Catalyzes conversion between 2- phosphoglycerate and phosphoenolpyruvate – Uses metal ions for electrophilic catalysis – Uses general acid/base catalysis
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Lecture12 - BCH 227 FALL 2010 LECTURE 12: STRUCTURE &...

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